LHX2 information

LHX2
Identifiers
Aliases	LHX2, LH2, hLhx2, LIM homeobox 2
External IDs	OMIM: 603759; MGI: 96785; HomoloGene: 55848; GeneCards: LHX2; OMA:LHX2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	124,033,301 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	38,259,745 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; ganglionic eminence; ; sperm; ; retinal pigment epithelium; ; endothelial cell; ; entorhinal cortex; ; middle temporal gyrus; ; Brodmann area 23; ; amygdala; ; postcentral gyrus;
	Top expressed in
	olfactory epithelium; ; ganglionic eminence; ; lip; ; septum transversum; ; barrel cortex; ; hand; ; hippocampus proper; ; hepatic diverticulum; ; medial ganglionic eminence; ; prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; sequence-specific DNA binding; chromatin binding; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus; intracellular anatomical structure;
Biological process	negative regulation of transcription regulatory region DNA binding; mesoderm development; telencephalon development; neural tube closure; retina development in camera-type eye; cerebral cortex development; transcription, DNA-templated; axon guidance; axon extension; hair follicle development; maintenance of epithelial cell apical/basal polarity; neurogenesis; brain development; olfactory bulb development; nervous system development; dorsal/ventral pattern formation; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; neuron differentiation; anatomical structure formation involved in morphogenesis; telencephalon regionalization; transcription by RNA polymerase II; negative regulation of gene expression, epigenetic; negative regulation of neurogenesis; positive regulation of neural precursor cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9355
	16870
	ENSG00000106689
	ENSMUSG00000000247
	P50458
	Q9Z0S2
	NM_004789
	NM_001290646; NM_010710
	NP_004780
	NP_001277575; NP_034840
	Wikidata
View/Edit Human	View/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.^[5]^[6]^[7]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106689 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000247 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.
^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.
^ ^a ^b "Entrez Gene: LHX2 LIM homeobox 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106689 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000247 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8649822-5] Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.

[pmid10051612-6] Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.

[entrez-7] "Entrez Gene: LHX2 LIM homeobox 2".

LHX2 information

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