Indoramin information

Indoramin
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C02CA02 (WHO) ;
Identifiers
	IUPAC name N-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}benzamide;
CAS Number	26844-12-2 ;
PubChem CID	33625;
IUPHAR/BPS	501;
DrugBank	DB08950 ;
ChemSpider	31014 ;
UNII	0Z802HMY7H;
KEGG	D04531 ;
ChEMBL	ChEMBL279516 ;
CompTox Dashboard (EPA)	DTXSID7048370 ;
ECHA InfoCard	100.043.659
Chemical and physical data
Formula	C22H25N3O
Molar mass	347.462 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccccc1)NC4CCN(CCc3c2ccccc2[nH]c3)CC4;
	InChI InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26) ; Key:JXZZEXZZKAWDSP-UHFFFAOYSA-N ;
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Indoramin (trade names Baratol and Doralese) is a piperidine antiadrenergic agent.

It is an alpha-1 selective adrenoceptor antagonist^[1] with direct myocardial depression action; therefore, it results in no reflex tachycardia. It is also used in benign prostatic hyperplasia (BPH).^[2]

It is commonly synthesized from tryptophol.^[3]

^ Pierce V, Shepperson NB, Todd MH, Waterfall JF (February 1986). "Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin". British Journal of Pharmacology. 87 (2): 433–441. doi:10.1111/j.1476-5381.1986.tb10834.x. PMC 1916533. PMID 3955309.
^ "Indoramin 20mg tablets". Medicines.org.uk. April 20, 2011. Archived from the original on July 25, 2022. Retrieved September 30, 2012.
^ Ullman's encyclopedia of Industrial Chemistry, Sixth Edition, 2002.

[pmid3955309-1] Pierce V, Shepperson NB, Todd MH, Waterfall JF (February 1986). "Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin". British Journal of Pharmacology. 87 (2): 433–441. doi:10.1111/j.1476-5381.1986.tb10834.x. PMC 1916533. PMID 3955309.

[2] "Indoramin 20mg tablets". Medicines.org.uk. April 20, 2011. Archived from the original on July 25, 2022. Retrieved September 30, 2012.

[3] Ullman's encyclopedia of Industrial Chemistry, Sixth Edition, 2002.

Indoramin information

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