Buspirone, sold under the brand name Buspar, among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder.[10][11] It is a serotonin 5-HT1A receptor agonist, increasing action at serotonin receptors in the brain.[3] It is taken orally, and takes two to six weeks to be fully effective.[10][11]
Common side effects of buspirone include nausea, headaches, dizziness, and difficulty concentrating.[10][12] Serious side effects may include movement disorders, serotonin syndrome, and seizures.[12] Its use in pregnancy appears to be safe but has not been well studied, and use during breastfeeding has not been well studied.[12][13]
Buspirone was developed in 1968 and approved for medical use in the United States in 1986.[10][11] It is available as a generic medication.[12] In 2021, it was the 53rd most-commonly prescribed medication in the United States, with more than 12million prescriptions.[14][15]
^Cite error: The named reference Elks2014 was invoked but never defined (see the help page).
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ abLoane C, Politis M (June 2012). "Buspirone: what is it all about?". Brain Research. 1461: 111–118. doi:10.1016/j.brainres.2012.04.032. PMID 22608068. S2CID 11734819.
^ abc"buspirone (Rx) - BuSpar, Buspirex, more." Medscape Reference. WebMD. Retrieved 14 November 2013.
^Cite error: The named reference pmid3515929 was invoked but never defined (see the help page).
^Cite error: The named reference SchatzbergNemeroff2009 was invoked but never defined (see the help page).
^Cite error: The named reference pmid17494642 was invoked but never defined (see the help page).
^ abMahmood I, Sahajwalla C (April 1999). "Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug". Clinical Pharmacokinetics. 36 (4): 277–287. doi:10.2165/00003088-199936040-00003. PMID 10320950. S2CID 1102318.
^Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, et al. (April 2005). "Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes". Drug Metabolism and Disposition. 33 (4): 500–507. doi:10.1124/dmd.104.000836. PMID 15640381. S2CID 10142905.
^ abcd"Buspirone Hydrochloride Monograph for Professionals". Drugs.com.
Buspirone, sold under the brand name Buspar, among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized...
Side effects of buspirone by incidence include: Very common (>10% incidence) Dizziness/lightheadedness Headache Somnolence (sleepiness) Common (1–10%...
anxiety disorders due to their fast onset but carry the risk of dependence. Buspirone is indicated for GAD, which has much slower onset but with the advantage...
A number of pyrimidinylpiperazine derivatives are drugs, including: Buspirone – anxiolytic Dasatinib – anticancer agent Eptapirone – anxiolytic Gepirone –...
to moderate cerebellar ataxia may be treatable with buspirone. It is thought that the buspirone increases the serotonin levels in the cerebellum and...
the D2 receptor (30- to 50-fold lower in comparison to buspirone). However, similarly to buspirone, gepirone metabolizes into 1-(2-pyrimidinyl)piperazine...
specific type of receptor. E.g. buspirone is a selective agonist for serotonin 5-HT1A. Partial agonists (such as buspirone, aripiprazole, buprenorphine,...
azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone. Tandospirone was introduced for medical use in Japan in...
the brain and decrease the release of serotonin. The anxiolytic drug Buspirone acts as partial agonist against these receptors. Selective serotonin reuptake...
have been classed as partial agonists at particular receptors include buspirone, aripiprazole, buprenorphine, nalmefene and norclozapine. Examples of...
Insufficient data were available to compare the drug with benzodiazepines and buspirone. Hydroxyzine can also be used for the treatment of allergic conditions...
Benzoctamine Benzquinamide Biperiden Brexpiprazole Brivaracetam Bupropion Buspirone Butaperazine Butriptyline Cannabidiol - Synthetic form with no other cannabinoid...
cause jaw pain/jaw spasm reversible syndrome (although it is not common). Buspirone appears to be successful in treating bruxism on SSRI/SNRI induced jaw...
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