Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic[2] used to treat schizophrenia and bipolar disorder.[2] It is taken either by mouth or by injection (subcutaneous or intramuscular).[2] The injectable versions are long-acting and last for 2–4 weeks.[9]
Common side effects include severe depression, movement problems, sleepiness, dizziness, trouble seeing, constipation, and increased weight.[2][10] Serious side effects may include the potentially permanent movement disorder tardive dyskinesia, as well as neuroleptic malignant syndrome, an increased risk of suicide, and high blood sugar levels.[2][9] In older people with psychosis as a result of dementia, it may increase the risk of death.[2] It is unknown if it is safe for use in pregnancy.[2] Its mechanism of action is not entirely clear, but is believed to be related to its action as a dopamine and serotonin antagonist.[2]
Study of risperidone began in the late 1980s and it was approved for sale in the United States in 1993.[2][11][7] It is on the World Health Organization's List of Essential Medicines.[12] It is available as a generic medication.[9] In 2021, it was the 138th most commonly prescribed medication in the United States, with more than 4million prescriptions.[13][14]
^Cite error: The named reference generics was invoked but never defined (see the help page).
^ abcdefghijklmn"Risperidone". The American Society of Health-System Pharmacists. Archived from the original on 2 December 2015. Retrieved 1 December 2015.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^"Risperdal Product information". Health Canada. 28 March 2019. Archived from the original on 2 April 2024. Retrieved 2 April 2024.
^"Risperdal Consta 25 mg powder and solvent for prolonged-release suspension for injection - Summary of Product Characteristics (SmPC)". (emc). 6 December 2018. Archived from the original on 30 January 2022. Retrieved 29 January 2022.
^ ab"Risperdal- risperidone tablet Risperdal M-Tab- risperidone tablet, orally disintegrating Risperdal- risperidone solution". DailyMed. Archived from the original on 30 April 2017. Retrieved 31 December 2019.
^"Okedi EPAR". European Medicines Agency (EMA). 15 December 2021. Archived from the original on 3 March 2022. Retrieved 2 March 2022.
^ abcHamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. pp. 434–435. ISBN 9781284057560.
^Hasnain M, Vieweg WV, Hollett B (July 2012). "Weight gain and glucose dysregulation with second-generation antipsychotics and antidepressants: a review for primary care physicians". Postgraduate Medicine. 124 (4): 154–67. doi:10.3810/pgm.2012.07.2577. PMID 22913904. S2CID 39697130.
^Schatzberg AF, Nemeroff CB (2009). The American Psychiatric Publishing textbook of psychopharmacology (4th ed.). Washington, D.C.: American Psychiatric Pub. p. 627. ISBN 9781585623099.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Risperidone - Drug Usage Statistics". ClinCalc. Archived from the original on 29 April 2017. Retrieved 14 January 2024.
Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It is taken...
This is a list of adverse effects of risperidone. Risperidone, sold under the brand name Risperdal among others, is an antipsychotic. It is used to treat...
Hyperprolactinaemia (seems to cause comparable prolactin elevation to its parent drug, risperidone) Sexual Dysfunction Common (1–10% incidence) Cough Extrapyramidal side...
the efficacy, tolerability and safety of adjunctive pimavanserin to risperidone and haloperidol were published in November 2012, and the results showed...
dopamine receptors responsible for control of prolactin release. Of these, risperidone is the most notorious for causing this complication. Case reports suggest...
longer-terms the risks of adverse effects complicate the choice. In turn, risperidone, olanzapine, and aripiprazole have been recommended for the treatment...
first-line treatments are aripiprazole, haloperidol, quetiapine, and risperidone. It is recommended in combination with fluoxetine as a first-line therapy...
treatment with risperidone. There was a case study in 2013 where oral risperidone was also successful for treating HPPD. In other cases risperidone has shown...
introduction of clozapine in the early 1970s followed by others (e.g., risperidone). Both generations of medication block receptors in the brain for dopamine...
nefazodone, mirtazapine, topiramate, clomiphene, oral contraceptives, and risperidone have been reported to cause illusory palinopsia. A patient frequently...
than olanzapine and risperidone; produce fewer movement related side effects than paliperidone, aripiprazole, ziprasidone, risperidone and olanzapine; and...
to other medium-potency antipsychotics and the atypical antipsychotic risperidone. When used for its strong antiemetic or antivertignosic effects in cases...
elevate prolactin levels, however, medications in this class such as risperidone and paliperidone carry the highest potential to induce hyperprolactinemia...
Pharmacological treatments may also be useful; the atypical antipsychotics risperidone and aripiprazole are empirically validated for alleviating co-morbid...
$8 billion in punitive damages to plaintiffs tied to the use of risperidone. Risperidone is an atypical antipsychotic that was originally approved to treat...
(antipsychotic, against mental illness such as schizophrenia. Active substance: risperidone) Eight original Janssen drugs have been included on the WHO Model List...
mainstay of treatment is antipsychotic medication, including olanzapine and risperidone, along with counseling, job training and social rehabilitation. Up to...
drugs. The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined. D2 receptors are coupled to Gi subtype of G protein...
thioridazine, clozapine, olanzapine, aripiprazole, and low doses of risperidone. Rabbit syndrome can be treated with anticholinergic drugs. It generally...
(Latuda), thioridazine, quetiapine (Seroquel), olanzapine (Zyprexa), risperidone and ziprasidone (Geodon) but not haloperidol Dopamine agonists used in...
mania and mixed episodes than most other antipsychotic drugs such as risperidone and olanzapine (with the exception of ziprasidone). Drop-out rates (in...
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