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Tamsulosin information


Tamsulosin
Clinical data
Pronunciation/tæmˈsləsɪn/[1]
tam-SOO-lə-sin
Trade namesFlomax, others
AHFS/Drugs.comMonograph
MedlinePlusa698012
License data
  • US DailyMed: Tamsulosin
Pregnancy
category
  • AU: B2
Routes of
administration
By mouth
ATC code
  • G04CA02 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only[2]
  • UK: POM (Prescription only)[3][4]
  • US: ℞-only[5]
Pharmacokinetic data
Bioavailability100% (by mouth)
MetabolismLiver
Elimination half-life9–13 hours
Excretion76% Kidney
Identifiers
IUPAC name
  • (R)-5-(2-{[2-(2-Ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide
CAS Number
  • 106133-20-4 checkY
PubChem CID
  • 129211
IUPHAR/BPS
  • 488
DrugBank
  • DB00706 checkY
ChemSpider
  • 114457 checkY
UNII
  • G3P28OML5I
KEGG
  • D08560 checkY
  • as HCl: D01024 checkY
ChEBI
  • CHEBI:9398 checkY
ChEMBL
  • ChEMBL836 checkY
CompTox Dashboard (EPA)
  • DTXSID3023631 Edit this at Wikidata
ECHA InfoCard100.109.780 Edit this at Wikidata
Chemical and physical data
FormulaC20H28N2O5S
Molar mass408.51 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CCOc1ccccc1OCCN[C@@H](C)Cc1ccc(OC)c(c1)S(=O)(=O)N
InChI
  • InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 checkY
  • Key:DRHKJLXJIQTDTD-OAHLLOKOSA-N checkY
  (verify)
Tamsulosin – ARISTO Pharma – 0.4 mg prolonged-release tablets – Urologikum

Tamsulosin, sold under the brand name Flomax among others, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis and to help with the passage of kidney stones.[6][7][8] The evidence for benefit with a kidney stone is better when the stone is larger.[8] Tamsulosin is taken by mouth.[6]

Common side effects include dizziness, headache, sleeplessness, nausea, blurry vision, and sexual problems.[9][6] Other side effects may include feeling lightheaded with standing due to changes in blood pressure, and angioedema.[9] Tamsulosin is an alpha blocker and works by relaxing muscles in the prostate.[10] Specifically it is an α1 adrenergic receptor blocker.[6]

Tamsulosin was approved for medical use in the United States in 1997.[6] It is available as a generic medication.[9] In 2021, it was the 24th most commonly prescribed medication in the United States, with more than 23 million prescriptions.[11][12]

  1. ^ "Tamsulosin". Merriam-Webster.com Dictionary.
  2. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  3. ^ "Flomaxtra XL, 400 micrograms, film-coated prolonged release tablet – Summary of Product Characteristics (SmPC)". (emc). 12 November 2019. Retrieved 2 December 2021.
  4. ^ "Faramsil 400 microgram Prolonged-release Tablets – Summary of Product Characteristics (SmPC)". (emc). 4 November 2020. Retrieved 2 December 2021.
  5. ^ "Flomax– tamsulosin hydrochloride capsule". DailyMed. Retrieved 2 December 2021.
  6. ^ a b c d e "Tamsulosin Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 24 December 2018.
  7. ^ "Prostatitis". NHS. 19 October 2017. Retrieved 24 December 2018.
  8. ^ a b Wang RC, Smith-Bindman R, Whitaker E, Neilson J, Allen IE, Stoller ML, Fahimi J (March 2017). "Effect of Tamsulosin on Stone Passage for Ureteral Stones: A Systematic Review and Meta-analysis". Annals of Emergency Medicine. 69 (3): 353–361.e3. doi:10.1016/j.annemergmed.2016.06.044. PMID 27616037.
  9. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 767. ISBN 9780857113382.
  10. ^ Hutchison LC, Sleeper RB (2010). Fundamentals of Geriatric Pharmacotherapy: An Evidence-Based Approach. ASHP. p. 209. ISBN 9781585283057.
  11. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  12. ^ "Tamsulosin –Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

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Tamsulosin

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Tamsulosin, sold under the brand name Flomax among others, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis...

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Intraoperative floppy iris syndrome

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with tamsulosin (e.g., Flomax), a medication widely prescribed for urinary symptoms associated with benign prostatic hyperplasia (BPH). Tamsulosin is a...

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Alpha blocker

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receptor antagonists include: Alfuzosin Doxazosin Prazosin (inverse agonist) Tamsulosin Terazosin Silodosin Selective α2-adrenergic receptor antagonists include:...

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List of GSK plc products

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ATC code G04

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G04CA02 Tamsulosin G04CA03 Terazosin G04CA04 Silodosin G04CA51 Alfuzosin and finasteride G04CA52 Tamsulosin and dutasteride G04CA53 Tamsulosin and solifenacin...

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List of sulfonamides

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antiarrhythmic) Ibutilide (class III antiarrhythmic) Sotalol (β blocker) Tamsulosin (α blocker) Udenafil (PDE5 inhibitor) Brinzolamide (carbonic anhydrase...

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Benign prostatic hyperplasia

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effects of naftopidil, tamsulosin and silodosin on urinary symptoms and quality of life may be similar. Naftopidil and tamsulosin may have similar levels...

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Aspermia

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of prostate surgery. It can also be caused by alpha blockers such as tamsulosin and silodosin. Another cause of aspermia is ejaculatory duct obstruction...

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Kidney stone disease

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or opioids. Larger calculi may be helped to pass with the medication tamsulosin or may require procedures such as extracorporeal shock wave lithotripsy...

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Alfuzosin

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and congested nose. Adverse effects of alfuzosin are similar to that of tamsulosin but with 70% lower rate of retrograde ejaculation. Alfuzosin contains...

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Retrograde ejaculation

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Retrograde ejaculation is a common side effect of medications, such as tamsulosin, that are used to relax the muscles of the urinary tract, treating conditions...

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Odynorgasmia

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resection are two treatments for ejaculatory duct obstruction. In one study, tamsulosin-treated patients' symptoms significantly improved after four weeks of...

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Nocturia

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for the symptoms of BPH in men. Doxazosin, terazosin, alfuzosin, and tamsulosin have all been well established in treatment to reduce lower urine tract...

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LSD

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Nifedipine

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that it helps to relieve renal colic. However, alpha blockers (such as tamsulosin) have been described as being significantly better. Nifedipine rapidly...

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Transurethral resection of the prostate

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normally initially treated medically through alpha antagonists such as tamsulosin, or 5-alpha-reductase inhibitors such as finasteride and dutasteride....

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Amitriptyline

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Prostate

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begins with an alpha-1 adrenergic receptor antagonist medication such as tamsulosin, which reduces the tone of the smooth muscle found in the urethra that...

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Haloperidol

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Urinary retention

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needle. Some people with BPH are treated with medications. These include tamsulosin to relax smooth muscles in the bladder neck, and finasteride and dutasteride...

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Tadalafil

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similar benefits for lower urinary tract symptoms as the usually prescribed tamsulosin. Tadalafil is approved in the United States, Canada, and Japan to improve...

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Beta blocker

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Astellas Pharma

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