Salbutamol, also known as albuterol and sold under the brand name Ventolin among others,[1] is a medication that opens up the medium and large airways in the lungs.[8] It is a short-acting β2 adrenergic receptor agonist that causes relaxation of airway smooth muscle.[8] It is used to treat asthma, including asthma attacks and exercise-induced bronchoconstriction, as well as chronic obstructive pulmonary disease (COPD).[8] It may also be used to treat high blood potassium levels.[9] Salbutamol is usually used with an inhaler or nebulizer, but it is also available in a pill, liquid, and intravenous solution.[8][10] Onset of action of the inhaled version is typically within 15 minutes and lasts for two to six hours.[8]
Common side effects include shakiness, headache, fast heart rate, dizziness, and feeling anxious.[8] Serious side effects may include worsening bronchospasm, irregular heartbeat, and low blood potassium levels.[8] It can be used during pregnancy and breastfeeding, but safety is not entirely clear.[8][11]
Salbutamol was patented in 1966 in Britain and became commercially available in the UK in 1969.[12][13] It was approved for medical use in the United States in 1982.[8] It is on the World Health Organization's List of Essential Medicines.[14] Salbutamol is available as a generic medication.[8] In 2021, it was the seventh most commonly prescribed medication in the United States, with more than 61million prescriptions.[15][16]
^ abCite error: The named reference brands was invoked but never defined (see the help page).
^Thereaputic Goods Administration (19 December 2018). "Prescribing medicines in pregnancy database". Australian Government.
^"Albuterol Use During Pregnancy". Drugs.com. 8 March 2019. Retrieved 21 December 2019.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Thereaputic Goods Administration. "Poisons Standard October 2017". Australian Government.
^"Prescription Drug List". Government of Canada. 23 October 2014.
^"Respiratory health". Health Canada. 9 May 2018. Retrieved 13 April 2024.
^ abcdefghijklm"Albuterol". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 8 December 2015. Retrieved 2 December 2015.
^Mahoney BA, Smith WA, Lo DS, Tsoi K, Tonelli M, Clase CM (April 2005). "Emergency interventions for hyperkalaemia". The Cochrane Database of Systematic Reviews. 2005 (2): CD003235. doi:10.1002/14651858.CD003235.pub2. PMC 6457842. PMID 15846652.
^Starkey ES, Mulla H, Sammons HM, Pandya HC (September 2014). "Intravenous salbutamol for childhood asthma: evidence-based medicine?" (PDF). Archives of Disease in Childhood. 99 (9): 873–7. doi:10.1136/archdischild-2013-304467. PMID 24938536. S2CID 2070868. Archived from the original (PDF) on 8 September 2017.
^Yaffe SJ (2011). Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk (9th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 32. ISBN 9781608317080. Archived from the original on 8 December 2015.
^Landau R (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. p. 226. ISBN 9780941901215. Archived from the original on 8 December 2015.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 542. ISBN 9783527607495.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Albuterol - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Salbutamol, also known as albuterol and sold under the brand name Ventolin among others, is a medication that opens up the medium and large airways in...
is inconclusive regarding the efficacy of levosalbutamol versus salbutamol or salbutamol-levosalbutamol combinations, though levosalbutamol is believed...
duration of action (up to 12 h) compared to short-acting β2 agonists such as salbutamol (albuterol), which are effective for 4 h to 6 h. Formoterol has a relatively...
Chesty/Forte Solvex Vasican Ventilate Forte (combination of bromhexine and salbutamol) Morton I, Hall J (1999). Concise Dictionary of Pharmacological Agents...
dilating effect on the bronchi, as when ipratropium is combined with salbutamol (albuterol — USAN) under the trade names Combivent (a non-aerosol metered-dose...
symptoms is usually with an inhaled short-acting beta2 agonist such as salbutamol and corticosteroids taken by mouth. In very severe cases, intravenous...
racemic mixture. Examples include thalidomide, ibuprofen, cetirizine and salbutamol. A well known drug that has different effects depending on its ratio of...
a calcium channel blocker such as diltiazem, or nifedipine ointment, salbutamol inhalation and topical nitroglycerine. For persistent cases, local anesthetic...
small impact on lung function, with patients remaining responsive to salbutamol (β2 -agonist) rescue therapy and endorses the use of bisoprolol in select...
receptors. Fenoterol has more cardiovascular toxicity than isoprenaline or salbutamol. Fenoterol was widely used in New Zealand in the late 1970s and the 1980s...
exercise or exposure to cold air. Some short-acting β-agonists, such as salbutamol, are specific to the lungs; they are called β2-adrenergic agonists and...
period of time. The primary noticeable difference of salmeterol from salbutamol, and other short-acting β2 adrenoreceptor agonists (SABAs), is its duration...
with a variety of their products, such as tiotropium and ipratropium/salbutamol. According to the manufacturer, the reusability of the inhaler reduces...
antibiotic azithromycin is used long-term. Inhaled hypertonic saline and salbutamol may also be useful. Lung transplantation may be an option if lung function...
rapidly reduce blood potassium levels include insulin with dextrose, salbutamol, and sodium bicarbonate. Medications that might worsen the condition should...
hypotension and the inhalation of a β2-mimetic such as hexoprenalin or salbutamol will terminate bronchospasms. Blood or plasma atenolol concentrations...
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