Recombinant human Interleukin-1 receptor antagonist protein; syn. N2-l-methionyl-interleukin 1 receptor antagonist (human isoform x reduced)
CAS Number
143090-92-0Y
DrugBank
DB00026Y
ChemSpider
none
UNII
9013DUQ28K
KEGG
D02934Y
ChEMBL
ChEMBL1201570N
Chemical and physical data
Formula
C759H1186N208O232S10
Molar mass
17257.66 g·mol−1
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Anakinra, sold under the brand name Kineret, is a biopharmaceutical medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still's disease.[3] It is a slightly modified recombinant version of the human interleukin 1 receptor antagonist protein.[3] It is marketed by Swedish Orphan Biovitrum.[1] Anakinra is administered by subcutaneous injection.[2]
^ ab"Kineret 100 mg solution for injection in a pre-filled syringe - Summary of Product Characteristics (SmPC)". UK Electronic Medicines Compendium. Retrieved 2 March 2022.
^ abCite error: The named reference Kineret FDA label was invoked but never defined (see the help page).
^ abc"Kineret EPAR". European Medicines Agency. 17 September 2018. Retrieved 20 July 2021. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
Anakinra, sold under the brand name Kineret, is a biopharmaceutical medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes...
considered an autoinflammatory disorder and is generally treated with anakinra, which inhibits interleukin 1. This treatment controls the condition but...
can be used to reduce the effects of the disorder. Anakinra is antagonist to IL-1 receptors. Anakinra binds the IL-1 receptor, preventing the actions of...
they quit their job as a consequence of their disease". Treatment using anakinra (Kineret) has been shown effective for FCAS, although this does mean daily...
Commissioning Policy: Anakinra for Haemophagocytic Lymphohistiocytosis (HLH) for adults and children in all ages, allowing Anakinra (a modified recombinant...
it. It should not be used in combination with anakinra or TNF antagonists. Because abatacept, anakinra, and TNF antagonists suppress the immune system...
neurotoxic effect. Anakinra is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein. Anakinra blocks the biologic...
cases are resistant to colchicine therapy alone. In these cases, adding anakinra to the daily colchicine regimen has been successful. Canakinumab, an...
action of interleukin 1; they cannot be taken in tablet form. These are anakinra, canakinumab and rilonacept. Rilonacept has been specifically approved...
disease (CMT) should avoid vincristine. A 2021 study has suggested that anakinra can reduce the neuropathy. Accidental injection of vinca alkaloids into...
the first female rabbi in Israel Kineret (medication), brand name of anakinra; no direct relation to the lake Kinneret, Israeli song based on Rachel...
IL-1β has become a common therapeutic target, and medications such as anakinra, rilonacept, and canakinumab have revolutionized the treatment of autoinflammatory...
2012 trial investigating if application of an IL-1 receptor antagonist (anakinra) would reduce fatigue in primary Sjögren's syndrome patients was inconclusive...
number of new medications are under study for treating gout, including anakinra, canakinumab, and rilonacept. Canakinumab may result in better outcomes...
In refractory cases treatment regimens are used similar to that in HLH. Anakinra is also effective. Cytokine release syndrome Grom AA, Mellins ED (September...
inhibitors (certolizumab, adalimumab, infliximab and etanercept), abatacept, anakinra, and auranofin. Additionally, rituximab and tocilizumab are monoclonal...
tumor necrosis factor (TNF) (infliximab, etanercept) and interleukin-1 (anakinra) have shown a good response in resistant arthritis and pyoderma gangrenosum...
Administration. 27 May 2009. Archived from the original on 20 August 2009. "Anakinra (Kineret) to be deleted from the PBS". National Prescribing Service Limited...
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