Structure of an antigen binding fragment of an antibody.
Identifiers
Symbol
ig
Pfam
PF00047
Pfam clan
CL0159
InterPro
IPR013151
PROSITE
PDOC00262
SCOP2
8fab / SCOPe / SUPFAM
OPM superfamily
193
OPM protein
5f71
CDD
cd00096
Membranome
2
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The immunoglobulin domain, also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology,[1][2] consisting of about 125 amino acids.
The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.
Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin, and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein–protein and protein–ligand interactions.[3]
^Bork P, Holm L, Sander C (September 1994). "The immunoglobulin fold. Structural classification, sequence patterns and common core". J. Mol. Biol. 242 (4): 309–20. doi:10.1006/jmbi.1994.1582. PMID 7932691.
^Williams AF, Barclay AN (1988). "The immunoglobulin superfamily—domains for cell surface recognition". Annu. Rev. Immunol. 6: 381–405. doi:10.1146/annurev.iy.06.040188.002121. PMID 3289571.
and 22 Related for: Immunoglobulin domain information
The immunoglobulindomain, also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel...
An antibody (Ab) is the secreted form of a B cell receptor; the term immunoglobulin (Ig) can refer to either the membrane-bound form or the secreted form...
structural features with immunoglobulins (also known as antibodies); they all possess a domain known as an immunoglobulindomain or fold. Members of the...
series of immunoglobulindomains, usually with one variable domain (VH) that is important for binding antigen and several constant domains (CH1, CH2,...
γ-macroglobulin, and subsequently termed IgM—M for “macro”. The V domains of normal immunoglobulin are highly heterogeneous, reflecting their role in protecting...
The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). A typical antibody is composed of two immunoglobulin (Ig)...
Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found...
portion of the protein contains 6 domains: 5 evolutionary conserved immunoglobulin-like domains, and 1 non-homologous domain, which is involved in proteolytic...
referred to as protein domains (244 copies in total): type I fibronectin type III domain (132 copies) and type II immunoglobulindomain (112 copies). However...
Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that...
Poliovirus receptor related immunoglobulindomain containing is a protein that in humans is encoded by the PVRIG gene. GRCh38: Ensembl release 89: ENSG00000213413...
"Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody...
vertebrates. The jawed vertebrates diversify their repertoire of immunoglobulindomain-based T and B cell antigen receptors mainly through the rearrangement...
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has been found only in mammals. IgE is synthesised by plasma cells...
Rabies immunoglobulin (RIG) is a medication made up of antibodies against the rabies virus. It is used to prevent rabies following exposure. It is given...
Transmembrane immunoglobulin and munin domain (TIM) proteins are a family of cell surface immunomodulatory proteins. TIM1 Kane LP (March 2010). "T cell...
Myotilin (myofibrillar titin-like protein) also known as TTID (TiTin ImmunoglobulinDomain) is a muscle protein that is found within the Z-disc of sarcomeres...
V-set and immunoglobulindomain containing 1 is a protein that in humans is encoded by the VSIG1 gene. This gene encodes a member of the junctional adhesion...
Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually...
(GPI) anchored conserved cell surface protein with a single V-like immunoglobulindomain, originally discovered as a thymocyte antigen. Thy-1 can be used...
believed to adopt either a single β-barrel or two-domain folded structure with standard immunoglobulindomains. The J chain's primary structure is unusually...
Global Information