Flumezapine information

Flumezapine
Identifiers
	IUPAC name 7-Fluoro-2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno(2,3b)(1,5)benzodiazepine;
CAS Number	61325-80-2;
PubChem CID	43602;
UNII	NA9GM10X6C;
KEGG	D02659;
ChEMBL	ChEMBL273786;
CompTox Dashboard (EPA)	DTXSID60976813 ;
Chemical and physical data
Formula	C17H19FN4S
Molar mass	330.43 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC2=C(NC3=C(C=CC(=C3)F)N=C2S1)N4CCN(CC4)C;

Flumezapine is an abandoned, investigational antipsychotic drug that was studied for the treatment of schizophrenia. Flumezapine failed clinical trials due to concern for liver and muscle toxicity. Flumezapine is structurally related to the common antipsychotic olanzapine—a point that was used against its manufacturer, Eli Lilly and Company, in a lawsuit in which generic manufacturers sought to void the patent on brand name olanzapine (Zyprexa). Although flumezapine does not differ greatly from olanzapine in terms of its structure, the difference was considered to be non-obvious, and Eli Lilly's patent rights on Zyprexa were upheld.

Flumezapine information

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Identifiers


IUPAC name 7-Fluoro-2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno(2,3b)(1,5)benzodiazepine
CAS Number	61325-80-2
PubChem CID	43602
UNII	NA9GM10X6C
KEGG	D02659
ChEMBL	ChEMBL273786
CompTox Dashboard (EPA)	DTXSID60976813
Chemical and physical data
Formula	C₁₇H₁₉FN₄S
Molar mass	330.43 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC2=C(NC3=C(C=CC(=C3)F)N=C2S1)N4CCN(CC4)C