Global InformationQuetiapine information
 | |
 | |
| Clinical data | |
|---|---|
| Pronunciation | /kwɪˈtaɪ.əpiːn/ kwi-TY-ə-peen |
| Trade names | Seroquel, Seroquel XR, Temprolide, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a698019 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | By mouth |
| Drug class | Atypical antipsychotic |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 100%[4] |
| Protein binding | 83%[5] |
| Metabolism | Liver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[8] |
| Elimination half-life | 7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)[5][6] |
| Excretion | Kidney (73%), feces (20%)[4][5][6][7] |
| Identifiers | |
IUPAC name
| |
| CAS Number |
|
| PubChem CID |
|
| IUPHAR/BPS |
|
| DrugBank |
|
| ChemSpider |
|
| UNII |
|
| KEGG |
|
| ChEBI |
|
| ChEMBL |
|
| CompTox Dashboard (EPA) |
|
| ECHA InfoCard | 100.131.193 |
| Chemical and physical data | |
| Formula | C21H25N3O2S |
| Molar mass | 383.51 g·mol−1 |
| 3D model (JSmol) |
|
| Solubility in water | 3.29 mg/mL (20 °C) |
SMILES
| |
InChI
| |
| (verify) | |
Quetiapine, sold under the brand name Seroquel among others, is an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.[9][10] Despite being widely used as a sleep aid due to its sedating effect, the benefits of such use may not outweigh its undesirable side effects.[11] It is taken orally.[9]
Common side effects include sleepiness, constipation, weight gain, and dry mouth.[9] Other side effects include low blood pressure with standing, seizures, a prolonged erection, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome.[9] In older people with dementia, its use increases the risk of death.[9] Use in the third trimester of pregnancy may result in a movement disorder in the baby for some time after birth.[9] Quetiapine is believed to work by blocking a number of receptors, including those for serotonin and dopamine.[9]
Quetiapine was developed in 1985 and approved for medical use in the United States in 1997.[9][12] It is available as a generic medication.[13] In 2021, it was the 62nd most commonly prescribed medication in the United States, with more than 10 million prescriptions.[14][15] It is on the World Health Organization's List of Essential Medicines.[16]
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
- ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
- ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
- ^ a b "quetiapine (Rx) - Seroquel, Seroquel XR". Medscape Reference. WebMD. Archived from the original on 20 October 2013. Retrieved 11 October 2013.
- ^ a b c "Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics". electronic Medicines Compendium. Sandoz. January 2013. Archived from the original on 20 October 2013. Retrieved 20 October 2013.
- ^ a b Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
- ^ "Quetiapine fumarate tablet". DailyMed. Ascend Laboratories, LLC. October 2013. Archived from the original on 2 December 2013. Retrieved 26 November 2013.
- ^ Brunton L, Chabner B, Knollman B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). McGraw Hill Professional. ISBN 978-0071624428.
- ^ a b c d e f g h "Quetiapine Fumarate". The American Society of Health-System Pharmacists. Archived from the original on 29 August 2017. Retrieved 26 March 2017.
- ^ Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S (December 2010). "Second-generation antipsychotics for major depressive disorder and dysthymia". The Cochrane Database of Systematic Reviews (12): CD008121. doi:10.1002/14651858.CD008121.pub2. PMID 21154393.
- ^ Anderson SL, Vande Griend JP (March 2014). "Quetiapine for insomnia: A review of the literature" (PDF). American Journal of Health-System Pharmacy. 71 (5): 394–402. doi:10.2146/ajhp130221. PMID 24534594. S2CID 207292819. Archived from the original (PDF) on 19 February 2020.
- ^ Riedel M, Müller N, Strassnig M, Spellmann I, Severus E, Möller HJ (April 2007). "Quetiapine in the treatment of schizophrenia and related disorders". Neuropsychiatric Disease and Treatment. 3 (2): 219–235. doi:10.2147/nedt.2007.3.2.219. PMC 2654633. PMID 19300555.
- ^ British national formulary: BNF 74 (74 ed.). British Medical Association. 2017. p. 383. ISBN 978-0857112989.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Quetiapine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.