Ergometrine, also known as ergonovine and sold under the brand names Ergotrate, Ergostat, and Syntometrine among others, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth.[4][1] It can be used either by mouth, by injection into a muscle, or injection into a vein.[4] It begins working within 15 minutes when taken by mouth and is faster in onset when used by injection.[4] Effects last between 45 and 180 minutes.[4]
Common side effect include high blood pressure, vomiting, seizures, headache, and low blood pressure.[4] Other serious side effects include ergotism.[4] It was originally made from the rye ergot fungus but can also be made from lysergic acid.[5][6] Ergometrine is regulated because it can be used to make lysergic acid diethylamide (LSD).[7]
Ergometrine was discovered in 1932.[5] It is on the World Health Organization's List of Essential Medicines.[8][9]
^ abMorton IK, Hall JM (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 113–. ISBN 978-0-7514-0499-9.
^Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 397–. ISBN 978-3-88763-075-1.
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-15.
^ abcdef"Ergonovine Maleate". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-25. Retrieved 1 December 2015.
^ abRavina E (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1st ed.). Weinheim: Wiley-VCH. p. 245. ISBN 9783527326693. Archived from the original on 2015-12-26.
^Sneader W (2005). Drug Discovery: a History (Rev. and updated ed.). Chichester: Wiley. p. 349. ISBN 9780471899792. Archived from the original on 2015-12-26.
^King LA (2009). Forensic chemistry of substance misuse : a guide to drug control. Cambridge, UK: Royal Society of Chemistry. p. 190. ISBN 9780854041787. Archived from the original on 2015-12-26.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Ergometrine, also known as ergonovine and sold under the brand names Ergotrate, Ergostat, and Syntometrine among others, is a medication used to cause...
uterine wall. Ergometrine, also known as ergonovine. Ergometrine is the first drug to be isolated from the rye ergot fungus. Ergometrine is often used...
alkaloid and ergometrine were particularly striking, but ergometrine was less toxic to rabbits (the approximate intravenous LD50 of ergometrine was 3.5mg/kg)...
5-HT5A, and 5-HT7 receptors. Methylergometrine is a synthetic analogue of ergometrine, a psychedelic alkaloid found in ergot, and many species of morning glory...
Albert Hofmann reported the first total synthesis of an ergot alkaloid, ergometrine. Though the synthesis found no industrial application, this was a huge...
concentration of 0.325% of dry weight. A more recent study reported presence of ergometrine, lysergol, lysergic acid and other alkaloids that contribute to its pharmacological...
the characteristics and medical benefits of the ergot alkaloids of ‘Ergometrine’, the drug credited with saving hundreds of thousands of women’s lives...
placental retention. It is useful ensuring the bladder is empty. However, ergometrine should not be given as it causes tonic uterine contractions which may...
is the uterus not contracting well. A combination of syntocinon and ergometrine is commonly used as part of active management of the third stage of labour...
the uterus in retained products Pessary in prolapse or retroversion. Ergometrine so often prescribed to enhance the involution process by reducing the...
the following groups: Water-soluble aminoalcohol derivatives, such as ergometrine and its isomer ergometrinine Water-insoluble polypeptide derivatives:...
she is pregnant; after reading the Turners' medical books, she steals ergometrine from Nonnatus House in an attempt to induce an abortion, but puts her...
synthesised starting from ergot; these include ergotamine, dihydroergotamine, ergometrine, ergocristine, ergocryptine, ergocornine, methysergide, bromocriptine...
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