Fenoldopam information

Fenoldopam
Clinical data
Trade names	Corlopam
AHFS/Drugs.com	Monograph
Routes of; administration	IV
ATC code	C01CA19 (WHO) ;
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Metabolism	Hepatic (CYP not involved)
Elimination half-life	5 minutes
Excretion	Renal (90%) and fecal (10%)
Identifiers
	IUPAC name (RS)-6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;
CAS Number	67227-56-9 ;
PubChem CID	3341;
IUPHAR/BPS	939;
DrugBank	DB00800 ;
ChemSpider	3224 ;
UNII	INU8H2KAWG;
KEGG	D07946 ;
ChEBI	CHEBI:5002 ;
ChEMBL	ChEMBL588 ;
CompTox Dashboard (EPA)	DTXSID0043896 ;
Chemical and physical data
Formula	C16H16ClNO3
Molar mass	305.76 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES Clc1c3c(cc(O)c1O)C(c2ccc(O)cc2)CNCC3;
	InChI InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2 ; Key:TVURRHSHRRELCG-UHFFFAOYSA-N ;
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Fenoldopam mesylate (Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D₁ receptor partial agonist.^[1] Fenoldopam is used as an antihypertensive agent.^[2] It was approved by the Food and Drug Administration (FDA) in September 1997.^[3]

^ Grenader A, Healy DP (July 1991). "Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells". The Journal of Pharmacology and Experimental Therapeutics. 258 (1): 193–198. PMID 1677038.
^ Oliver WC, Nuttall GA, Cherry KJ, Decker PA, Bower T, Ereth MH (October 2006). "A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta". Anesthesia and Analgesia. 103 (4): 833–840. doi:10.1213/01.ane.0000237273.79553.9e. PMID 17000789. S2CID 23684353.
^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved November 14, 2011.

[1] Grenader A, Healy DP (July 1991). "Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells". The Journal of Pharmacology and Experimental Therapeutics. 258 (1): 193–198. PMID 1677038.

[pmid17000789-2] Oliver WC, Nuttall GA, Cherry KJ, Decker PA, Bower T, Ereth MH (October 2006). "A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta". Anesthesia and Analgesia. 103 (4): 833–840. doi:10.1213/01.ane.0000237273.79553.9e. PMID 17000789. S2CID 23684353.

[3] "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved November 14, 2011.

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