adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of synaptic vesicle exocytosis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1812
13488
Ensembl
ENSG00000184845
ENSMUSG00000021478
UniProt
P21728
Q61616
RefSeq (mRNA)
NM_000794
NM_001291801 NM_010076
RefSeq (protein)
NP_000785
NP_001278730 NP_034206
Location (UCSC)
Chr 5: 175.44 – 175.44 Mb
Chr 13: 54.21 – 54.21 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Dopamine receptor D1, also known as DRD1. It is one of the two types of D1-like receptor family — receptors D1 and D5. It is a protein that in humans is encoded by the DRD1 gene.[5][6][7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000184845 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021478 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Dearry A, Gingrich JA, Falardeau P, Fremeau RT, Bates MD, Caron MG (September 1990). "Molecular cloning and expression of the gene for a human D1 dopamine receptor". Nature. 347 (6288): 72–76. Bibcode:1990Natur.347...72D. doi:10.1038/347072a0. PMID 2144334. S2CID 4281682.
^Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, et al. (September 1990). "Cloning and expression of human and rat D1 dopamine receptors". Nature. 347 (6288): 76–80. Bibcode:1990Natur.347...76Z. doi:10.1038/347076a0. PMID 2168520. S2CID 4313577.
^Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, et al. (September 1990). "Human dopamine D1 receptor encoded by an intronless gene on chromosome 5". Nature. 347 (6288): 80–83. Bibcode:1990Natur.347...80S. doi:10.1038/347080a0. PMID 1975640. S2CID 4236625.
^Mishra A, Singh S, Shukla S (2018-05-31). "Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson's disease". Journal of Experimental Neuroscience. 12: 1179069518779829. doi:10.1177/1179069518779829. PMC 5985548. PMID 29899667.
and 25 Related for: Dopamine receptor D1 information
DopaminereceptorD1, also known as DRD1. It is one of the two types of D1-like receptor family — receptorsD1 and D5. It is a protein that in humans is...
types of receptors for dopamine was first proposed in 1976. There are at least five subtypes of dopaminereceptors, D1, D2, D3, D4, and D5. The D1 and D5...
A dopamine agonist (DA) is a compound that activates dopaminereceptors. There are two families of dopaminereceptors, D1-like and D2-like. They are all...
Dopaminereceptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with...
dopamine antagonist, also known as an anti-dopaminergic and a dopaminereceptor antagonist (DRA), is a type of drug which blocks dopaminereceptors by...
Dopaminereceptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested...
activation of dopamine and norepinephrine receptors, specifically dopaminereceptorD1 and adrenoceptor α2, in the prefrontal cortex. Dopamine plays a role...
Therapeutic Chemical Classification System DopaminereceptorD1, a protein Haplogroup D1 (Y-DNA) Vitamin D1, a form of Vitamin D DI, Iodothyronine deiodinase...
containing mainly D1-type (i.e., DRD1 and DRD5) or D2-type (i.e., DRD2, DRD3, and DRD4) dopaminereceptors. A subpopulation of MSNs contain both D1-type and D2-type...
The dopaminereceptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. The structure of DRD4...
Dopaminereceptor D3 is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopaminereceptor. The D3 subtype...
stimulating beta-2 adrenergic receptors and peripheral dopamine receptorD1 and dopaminereceptor D2. It also inhibits the neuronal re-uptake of norepinephrine...
of the 5-HT2A receptor are sometimes used as atypical antipsychotics (contrast with typical antipsychotics, which are purely dopamine antagonists). They...
stimulation of dopamine and norepinephrine receptors. ... Beyond these general permissive effects, dopamine (acting via D1receptors) and norepinephrine...
have evidence in vitro as direct agonists or indirect agonists of dopaminereceptorD1 or adrenoceptor A2. Relatively high doses of stimulants cause cognitive...
show the drug to have moderate affinity to dopamine D2 receptors and low affinity to dopaminereceptorD1. Researchers are looking for alternatives to...
abnormal dopaminereceptor D2 structure, as well as a reduced link between dopaminereceptorD1 and receptor D2. Studies have shown that targeting the D1 receptors...
spiny neurons (MSNs) that express dopaminereceptorD1, muscarinic acetylcholine receptor M4, and adenosine receptor A1. The direct pathway has been proposed...
2015). "Rotigotine is a potent agonist at dopamineD1receptors as well as at dopamine D2 and D3 receptors". British Journal of Pharmacology. 172 (4):...
stimulation of dopamine and norepinephrine receptors. ... Beyond these general permissive effects, dopamine (acting via D1receptors) and norepinephrine...
large number of antipsychotics have dopamine-receptor antagonistic effects. The theory, however, does not posit dopamine overabundance as a complete explanation...
more slowly from the synaptic cleft and continues to activate the dopaminereceptors on the target cell. Until the early 20th century, scientists assumed...
express dopamineD1receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation...
stimulation of dopamine and norepinephrine receptors. ... Beyond these general permissive effects, dopamine (acting via D1receptors) and norepinephrine...
but not beta-adrenergic receptors. The encoded protein interacts with dopaminereceptorD1 and may interact with other DA receptor subtypes and/or GPCRs...
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