Parkinson's disease, hyperprolactinemia, restless legs syndrome
ATC code
N04BC
Biological target
Dopamine receptors
External links
MeSH
D010300
Legal status
In Wikidata
A dopamine agonist(DA) is a compound that activates dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all G protein-coupled receptors. D1- and D5-receptors belong to the D1-like family and the D2-like family includes D2, D3 and D4 receptors.[1] Dopamine agonists are primarily used in the treatment of Parkinson's disease, and to a lesser extent, in hyperprolactinemia and restless legs syndrome.[2] They are also used off-label in the treatment of clinical depression. The use of dopamine agonists is associated with impulse control disorders and dopamine agonist withdrawal syndrome (DAWS).[3]
^Cite error: The named reference :1 was invoked but never defined (see the help page).
^Cite error: The named reference :5 was invoked but never defined (see the help page).
^Elliott, Carl. "The Degradation Drug". The American Scholar. Retrieved 15 September 2022.
A dopamineagonist (DA) is a compound that activates dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all...
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic...
brain for dopamine. Other drugs act by binding to a receptor and mimicking the normal neurotransmitter. Such drugs are called receptor agonists. An example...
subsequently under many brand names, is an ergoline derivative and dopamineagonist that is used in the treatment of pituitary tumors, Parkinson's disease...
manner, older dopamineagonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over...
selectivity with dopamine receptors. Dinapsoline – full agonist with 5-fold selectivity for D1-like receptors over D2 Dinoxyline – full agonist with approximately...
mouth. Pramipexole is a dopamineagonist of the non-ergoline class. Pramipexole (and related D3-preferring dopamineagonist medications such as ropinirole)...
typically occurs in people with Parkinson's disease (PD) who have taken dopamineagonist medications for an extended period of time. It is characterized by...
tobacco use, and sleep hygiene. Medications used to treat RLS include dopamineagonists like pramipexole and gabapentinoids (α2δ ligands) like gabapentin...
targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. The existence of...
differential engagement at the dopamine receptor (D2). Aripiprazole is a partial agonist at dopamine D2 receptors, partial agonist at 5-HT1A receptors and an...
transmits dopamine. Some patients with akinetic mutism have shown to improve with levodopa or dopamineagonist therapy, or by repleting dopamine in the motivational...
the endogenous agonist for serotonin receptors is serotonin, and the endogenous agonist for dopamine receptors is dopamine. Full agonists bind to and activate...
pregnancy and breastfeeding is of unclear safety. It is a dopamineagonist and works by triggering dopamine D2 receptors. It was approved for medical use in the...
Rotigotine, sold under the brand name Neupro among others, is a dopamineagonist of the non-ergoline class of medications indicated for the treatment of...
ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Parkinson's disease is associated with reduced dopamine activity...
otherwise contraindicated, it is possible to treat using one of the dopamineagonists, bromocriptine or cabergoline. As tablets rather than injections,...
Lisuride acts as a mixed agonist and antagonist of dopamine, serotonin, and adrenergic receptors. Activation of specific dopamine receptors is thought to...
to dopamineagonist therapy, such that prolactin levels are still high or the tumor is not shrinking as expected, the dose of the dopamineagonist can...
sold under the brand names Almirid and Cripar among others, is a dopamineagonist of the ergoline group that is used as an antiparkinson agent in the...
primary endogenous agonist for serotonin receptors is serotonin, and the primary endogenous agonist for dopamine receptors is dopamine. In general, receptors...
supplementary role, and MRI is the only definitive diagnostic tool available. Dopamineagonist testing can, however, be used to determine the effectiveness of DAs...
taken by mouth. Cabergoline is an ergot derivative and a potent dopamine D2 receptor agonist. Cabergoline was patented in 1980 and approved for medical use...
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