Pair of enantiomers
Epinastine Trade names Alesion, Elestat, Purivist, Relestat AHFS/Drugs.com Monograph MedlinePlus a604011 Pregnancy category Routes of administration Eye drops ATC code R06AX24 (WHO ) S01GX10 (WHO ) Protein binding 64% Elimination half-life 12 hours
(RS )-3-amino-9,13b-dihydro-1H -dibenz(c,f)imidazo(1,5-a)azepine
CAS Number 80012-43-7 Y PubChem CID IUPHAR/BPS DrugBank DB00751 Y ChemSpider 3128 Y UNII KEGG D07900 Y ChEBI CHEBI:51032 Y ChEMBL ChEMBL1106 Y CompTox Dashboard (EPA ) DTXSID2048371 ECHA InfoCard 100.120.187 Formula C 16 H 15 N 3 Molar mass 249.317 g·mol−1 3D model (JSmol)
N\4=C(\N3c1c(cccc1)Cc2c(cccc2)C3C/4)N
InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18)
Y Key:WHWZLSFABNNENI-UHFFFAOYSA-N
Y
(verify)
Epinastine (brand names Alesion , Elestat , Purivist , Relestat ) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States.[1] It is highly selective for the H1 receptor and does not cross the blood-brain-barrier.[2]
It was patented in 1980 and came into medical use in 1994.[3]
^ Pradhan S, Abhishek K, Mah F (September 2009). "Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects". Expert Opinion on Drug Metabolism & Toxicology . 5 (9): 1135–1140. doi:10.1517/17425250903117284. PMID 19630694. S2CID 207490591.
^ Walther G, Daniel H, Bechtel WD, Brandt K (April 1990). "New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine". Arzneimittel-Forschung . 40 (4): 440–446. PMID 1972625.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery . John Wiley & Sons. p. 549. ISBN 9783527607495 .
Last Update: 2023-12-20T19:26:59Z
Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to...
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Last Update: 2024-05-23T00:14:08Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 1350
Last Update: 2024-05-05T17:54:36Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 4362
Last Update: 2024-04-02T05:19:08Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 6534
Last Update: 2024-05-20T10:26:11Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 9149
Last Update: 2024-05-05T10:21:42Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 1209
Last Update: 2024-05-25T11:10:50Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 2681
Last Update: 2024-04-05T05:21:37Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 1711
Last Update: 2024-02-09T06:06:26Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 1321
Last Update: 2024-05-14T07:00:43Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 2161
Last Update: 2024-05-24T17:48:58Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 8668
Last Update: 2024-05-25T19:38:42Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 10014
Last Update: 2024-05-29T16:56:49Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 6167
Last Update: 2024-03-28T19:23:24Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 8663
Last Update: 2024-01-22T04:39:46Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 3073
Last Update: 2024-03-08T02:40:07Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 2340
Last Update: 2024-04-15T07:00:01Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 1144
Last Update: 2024-05-20T13:48:36Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 5041
Last Update: 2024-05-27T05:06:01Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 2563
Last Update: 2024-05-25T02:25:35Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 4889
Last Update: 2023-12-19T21:21:39Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 1748
Last Update: 2024-05-26T23:14:51Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 1690
Last Update: 2024-05-25T02:04:04Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 3708
Last Update: 2024-05-28T08:03:44Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 5377
Last Update: 2024-05-29T19:34:52Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 12545
Last Update: 2024-05-16T04:06:32Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 8710
Last Update: 2024-05-25T02:00:20Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 5296
Last Update: 2024-05-14T00:33:04Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 1804
Last Update: 2024-04-07T05:21:49Z
Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine...
Word Count : 2575
Last Update: 2024-04-08T14:01:51Z
Promethazine Others: Antidepressants (e.g., doxepin, mirtazapine, trimipramine) Epinastine Latrepirdine Mebhydrolin Olopatadine Perlapine Phenindamine Pimethixene...
Word Count : 3138