"Dramamine" redirects here. For other uses, see Dramamine (disambiguation).
Dimenhydrinate
Combination of
Diphenhydramine
Antihistamine, sedative
8-chlorotheophylline
Stimulant
Clinical data
Trade names
Dramamine, Draminate, Gravol, others
AHFS/Drugs.com
Monograph
MedlinePlus
a607046
License data
US DailyMed: Dimenhydrinate
Pregnancy category
AU: A
Routes of administration
By mouth, rectal, intravascular, intramuscular
ATC code
R06AA11 (WHO) combinations R06AA61 (WHO)
Legal status
Legal status
AU: S2 (Pharmacy medicine)
CA: OTC
US: OTC
Pharmacokinetic data
Metabolism
Liver
Elimination half-life
5.5 hours[1] (diphenhydramine component)
Identifiers
CAS Number
523-87-5Y
PubChem CID
10660
DrugBank
DB00985Y
ChemSpider
10210Y
UNII
JB937PER5C
KEGG
D00520Y
ChEBI
CHEBI:94848
ChEMBL
ChEMBL1200406N
CompTox Dashboard (EPA)
DTXSID9025087
ECHA InfoCard
100.007.593
NY (what is this?)(verify)
Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate is a theoclate salt composed of diphenhydramine (an ethanolamine derivative) and 8-chlorotheophylline (a chlorinated theophylline derivative) in a 1:1 ratio.[2]
Dimenhydrinate was introduced to the market by G.D. Searle in 1949.[3][4]
^Scavone JM, Luna BG, Harmatz JS, von Moltke L, Greenblatt DJ (April 1990). "Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration". Biopharmaceutics & Drug Disposition. 11 (3): 185–189. doi:10.1002/bdd.2510110302. PMID 2328304.
^Zabirowicz ES, Gan TJ (2019). "34 - Pharmacology of Postoperative Nausea and Vomiting". In Hemmings Jr HC, Talmage ED (eds.). Pharmacology and Physiology for Anesthesia (Second ed.). Elsevier Inc. pp. 671–692. doi:10.1016/B978-0-323-48110-6.00034-X. ISBN 978-0-323-48110-6. S2CID 81387334.
^Newman A (21 June 2012). "New Dramamine Ads Take Aim at Summer Vacationers". The New York Times. Retrieved 26 June 2023.
^Grauer N (12 February 2019). "Hopkins History Moments: Neil A. Grauer explains how Hopkins expertise helped prevent seasickness". Johns Hopkins Medicine. Retrieved 27 June 2023.
Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate...
For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher...
identified as ethanolamines, which includes carbinoxamine, clemastine, dimenhydrinate, chlorphenoxamine, diphenhydramine and doxylamine. ETA molecules are...
not a recommended treatment. It can also be used as an antidote for dimenhydrinate or diphenhydramine poisoning. It has been shown to improve long-term...
effects of medication taken over a longer period. However, transdermal dimenhydrinate anti-nausea patches are typically used whenever space suits are worn...
useful: antimuscarinics such as scopolamine, H1 antihistamines such as dimenhydrinate, and amphetamines such as dexamphetamine. Side effects, however, may...
the first line treatment for pregnancy-related nausea and vomiting. Dimenhydrinate is an inexpensive and effective over the counter medication for preventing...
Dimedrol, Daedalon and Nytol), used as an antihistamine and sedative, and dimenhydrinate (brand names Dramamine, Driminate, Gravol, Gravamin, Vomex, and Vertirosan)...
diphenhydramine/8-chlorotheophylline combination product dimenhydrinate. As with dimenhydrinate, the stimulant effect of the etanautine counteracts the...
low. Some common combinations that are used recreationally include Dimenhydrinate (8-chlorotheophylline/diphenhydramine) – used to treat motion sickness...
Medications that may alleviate the symptoms of airsickness include: meclozine dimenhydrinate diphenhydramine scopolamine (available in both patch and oral form)...
manufacture, distribution, stocking, etc. Over-the-counter medicines: Dimenhydrinate (8-chlorotheophylline/diphenhydramine) — used to treat motion sickness...
therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind...
vomiting peripherally induced induced with syrup of ipecac. Unlike dimenhydrinate and acepromazine, which are used for motion sickness, maropitant does...
this group include bromodiphenhydramine, carbinoxamine, clemastine, dimenhydrinate, diphenhydramine, orphenadrine, and phenyltoloxamine. Doxylamine is...
Mental Health (disambiguation) Dimethylhydantoin Dimethylhydrazine Dimenhydrinate Marine Histories Doctorate (this a degree in underwater archaeology...
Global Information
(what is this?) (verify)