Emedastine information

Emedastine
Identifiers
	IUPAC name 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole;
CAS Number	87233-61-2 ;
UNII	9J1H7Y9OJV;
CompTox Dashboard (EPA)	DTXSID7048243 ;
Chemical and physical data
Formula	C17 H26 N4 O

Emedastine (trade name Emadine) is a second generation antihistamine used in eye drops to alleviate the symptoms of allergic conjunctivitis.^[1] It acts as a H₁ receptor antagonist. It works by blocking the action of histamine that causes allergic symptoms. It is used in form of the difumarate.^[2] The emedastine difumarate is a white, crystalline, water-soluble fine powder. Emedastine eye drops is usually applied twice a day to the affected eye. When the patients with allergic conjunctivitis were treated with 0.05% emedastine difumarate ophthalmic solution for six weeks, the signs and symptoms such as redness, itching and swelling of the eyes were relieved. Emedastine appears to be devoid of effects on adrenergic, dopaminergic and serotonin receptors. This drug was developed by Alcon, which is global medical company specializing in eye care products.

^ "Emedastine (Ophthalmic)". The American Society of Health-System Pharmacists. Archived from the original on 6 August 2019. Retrieved 11 February 2020.
^ Bielory L, Lien KW, Bigelsen S (2005). "Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis". Drugs. 65 (2): 215–28. doi:10.2165/00003495-200565020-00004. PMID 15631542. S2CID 46791611.

[AHFS2020-1] "Emedastine (Ophthalmic)". The American Society of Health-System Pharmacists. Archived from the original on 6 August 2019. Retrieved 11 February 2020.

[2] Bielory L, Lien KW, Bigelsen S (2005). "Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis". Drugs. 65 (2): 215–28. doi:10.2165/00003495-200565020-00004. PMID 15631542. S2CID 46791611.

Emedastine information

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Identifiers

IUPAC name 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole
CAS Number	87233-61-2^Y
UNII	9J1H7Y9OJV
CompTox Dashboard (EPA)	DTXSID7048243
Chemical and physical data
Formula	C₁₇ H₂₆ N₄ O