Mass formed in response to injury to the nervous system
Medical condition
Glial scar
Micrograph of the superficial cerebral cortex showing neuron loss and reactive astrocytes in a person who had a stroke. H&E-LFB stain.
Specialty
Pathology
Causes
Trauma
A glial scar formation (gliosis) is a reactive cellular process involving astrogliosis that occurs after injury to the central nervous system. As with scarring in other organs and tissues, the glial scar is the body's mechanism to protect and begin the healing process in the nervous system.
In the context of neurodegeneration, formation of the glial scar has been shown to have both beneficial and detrimental effects. Particularly, many neuro-developmental inhibitor molecules are secreted by the cells within the scar that prevent complete physical and functional recovery of the central nervous system after injury or disease.[citation needed] On the other hand, absence of the glial scar has been associated with impairments in the repair of the blood brain barrier.[1]
^Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV (March 2004). "Reactive astrocytes protect tissue and preserve function after spinal cord injury". J. Neurosci. 24 (9): 2143–55. doi:10.1523/JNEUROSCI.3547-03.2004. PMC 6730429. PMID 14999065.
A glialscar formation (gliosis) is a reactive cellular process involving astrogliosis that occurs after injury to the central nervous system. As with...
the proliferation associated with gliosis leads to the formation of a glialscar. The process of gliosis involves a series of cellular and molecular events...
(Llinás' law). Glial cell scar formation is induced following damage to the nervous system. In the central nervous system, this glialscar formation significantly...
Glia, also called glial cells (gliocytes) or neuroglia, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral...
improper GFAP regulation, and injury can cause glial cells to react in detrimental ways. Glialscarring is a consequence of several neurodegenerative conditions...
astrocytes, in response to infection for example, in severe cases causing glialscar formation that may inhibit axon regeneration. Reactive astrogliosis is...
to the development of a glialscar. There are multiple disorders associated with improper GFAP regulation and glialscarring is a consequence of several...
glialscar, and may contribute to neural repair. The role of astrocytes in CNS regeneration following injury is not well understood though. The glial...
senescence in the kidney has shown potential to limit renal fibrosis. Glialscar Myocardial fibrosis has two forms: Interstitial fibrosis, described in...
central nervous system where it participates both in development and in the glialscar formation following an injury. Keratan sulfates are large, highly hydrated...
form the glialscar composed of a proteoglycan matrix that hinders axonal regeneration. However, more recent studies revealed that glia scar is not detrimental...
including cartilage, and also play key roles in neural development and glialscar formation. They are known to be involved in certain cell processes, such...
scarring process in the central nervous system, forming glialscars. It has been proposed that a subtype of pericytes participates in this scarring in...
areas of the central nervous system. This damage forms a scar which is then termed a glialscar. The presence of inclusion bodies known as Papp–Lantos bodies...
increase rapidly at areas of injury in the CNS, including in the area of the glialscar of spinal cord contusion injury. NG2 interacts via its large extracellular...
neighboring neurons. Astrocytes that remain in an activated state form glialscars that also prevent the re-myelination of neurons, as they are a physical...
in degeneration of denervated and damaged neurons, the formation of a glialscar, and collateral sprouting of surviving neurons. PNNs have been shown to...
for multiple cerebro-spinal sclerosis, which refers to the numerous glialscars (or sclerae – essentially plaques or lesions) that develop on the white...
electrode, encapsulation of the electrode in fibrous tissue – known as a glialscar, or changes in the chemical environment around the electrode. Ohm's law...
by encapsulating the electrode itself in a protective layer called a "glialscar", (see 2.2). One serious impediment to understanding the tissue response...
tissues already damaged by the primary injury. It results in formation of a glialscar, which impedes axonal growth.Secondary injuries can occur from different...
to the damaged region of the central nervous system because they form glialscar tissue which inhibits both neuroplasticity and repair of damaged axons...
sclerosis can be pathologically defined as the presence of distributed glialscars (or sclerosis) in the central nervous system disseminated in time (DIT)...
appear Plaques in the white matter in MS are sharply delineated, while the glialscar in ADEM is smooth. Axons are better preserved in ADEM lesions. Inflammation...
Chondroitin sulfate proteoglycans suppress the extension of axons over the glialscar, a barrier which develops after lesioning the spinal cord. Proteoglycans...
nervous system (CNS) produce lesions (demyelinated areas in the CNS) and glialscars or scleroses. They present different shapes and histological findings...
attract the proximal axons. Another feature that results eventually is Glialscar formation. This further hinders chances for regeneration and reinnervation...
glial tissue. Further, a polyp usually has mucoserous glands. The lesion is frequently misinterpreted as scar in the subcutaneous tissues, but scar in...
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