positive regulation of cell population proliferation
interleukin-11-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3590
16158
Ensembl
ENSG00000137070
ENSMUSG00000078735
UniProt
Q14626
P70225
RefSeq (mRNA)
NM_001142784 NM_004512 NM_147162
NM_010550
RefSeq (protein)
NP_001136256
NP_001092818 NP_001365603
Location (UCSC)
Chr 9: 34.65 – 34.66 Mb
Chr 4: 42.66 – 42.67 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.[5]
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000137070 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000078735 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Interleukin-23 subunitalpha is a protein that in humans is encoded by the IL23A gene. The protein is also known as IL-23p19. It is one of the two subunits...
chains, termed alpha (CD25), beta (CD122) and gamma (CD132). The gamma chain is shared by all family members. The IL-2 receptor (IL-2R) α subunit binds IL-2...
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes...
with Interleukin 10 receptor, alphasubunit. The receptor complex for IL-10 also requires the IL10R2 chain to initiate signalling. This ligand–receptor combination...
As a signaling molecule, interleukin11 has a variety of functions associated with its receptorinterleukin11receptoralpha; such functions include placentation...
structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and...
two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase)...
multi-subunitreceptor with IL-4. This receptor is a heterodimer receptor complex consisting of alpha IL-4 receptor (IL-4Rα) and alphaInterleukin-13 receptor...
(CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF". The Journal of Biological Chemistry. 278 (11): 9528–9535. doi:10...
shown to interact with interleukin 5 receptoralphasubunit. The IL-5 receptor is composed of an α and a βc chain. The α subunit is specific for the IL-5...
effects of interleukin11. Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alphasubunit and a 40kDa beta subunit. It is involved...
(November 1996). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptorsubunits". Proceedings of the National Academy...
Global Information
