Carbinoxamine information

Carbinoxamine
Clinical data
Trade names	Clistin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a606008
Pregnancy; category	C;
Routes of; administration	Oral: 4 mg tablet or 4 mg/5 mL liquid
ATC code	R06AA08 (WHO) ;
Legal status
Legal status	US: 4 mg is FDA approved; In general: Over-the-counter (OTC);
Pharmacokinetic data
Elimination half-life	10 to 20 hours
Identifiers
	IUPAC name 2-[(4-Chlorophenyl)-pyridin-2-yl-methoxy]-N,N-; dimethyl-ethanamine;
CAS Number	486-16-8 ; maleate salt: 3505-38-2 ;
PubChem CID	2564;
IUPHAR/BPS	7139;
DrugBank	DB00748 ;
ChemSpider	2466 ;
UNII	982A7M02H5; maleate salt: 02O55696WH ;
KEGG	D07617 ;
ChEBI	CHEBI:3398 ;
ChEMBL	ChEMBL864 ;
CompTox Dashboard (EPA)	DTXSID4022737 ;
ECHA InfoCard	100.006.935
Chemical and physical data
Formula	C16H19ClN2O
Molar mass	290.79 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)C(OCCN(C)C)c2ncccc2;
	InChI InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3 ; Key:OJFSXZCBGQGRNV-UHFFFAOYSA-N ;
	(verify)

Carbinoxamine is an antihistamine and anticholinergic agent. It is used for hay fever, vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine.

It was patented in 1947 and came into medical use in 1953.^[1] It was first launched in the United States by the McNeil Corporation under the brand name Clistin. Carbinoxamine is available in various countries around the world by itself, combined with decongestants such as pseudoephedrine, and also with other ingredients including paracetamol, aspirin, and codeine.

^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 545. ISBN 9783527607495.

[Fis2006-1] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 545. ISBN 9783527607495.

Carbinoxamine information

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