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Ethanolamine information


Ethanolamine
Names
Preferred IUPAC name
2-Aminoethan-1-ol[1]
Other names
  • 2-Aminoethanol
  • 2-Amino-1-ethanol
  • Ethanolamine (not recommended[1])
  • Monoethanolamine
  • β-Aminoethanol
  • β-hydroxyethylamine
  • β-Aminoethyl alcohol
  • Glycinol
  • Olamine
  • MEA
  • Ethylolamine
  • 2-Hydroxyethylamine
  • Colamine
Identifiers
CAS Number
  • 141-43-5 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:16000 checkY
ChEMBL
  • ChEMBL104943 checkY
ChemSpider
  • 13835336 checkY
DrugBank
  • DB03994 checkY
ECHA InfoCard 100.004.986 Edit this at Wikidata
EC Number
  • 205-483-3
KEGG
  • D05074 checkY
PubChem CID
  • 700
RTECS number
  • KJ5775000
UNII
  • 5KV86114PT checkY
CompTox Dashboard (EPA)
  • DTXSID6022000 Edit this at Wikidata
InChI
  • InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2 checkY
    Key: HZAXFHJVJLSVMW-UHFFFAOYSA-N checkY
  • InChI=1/C2H7NO/c3-1-2-4/h4H,1-3H2
    Key: HZAXFHJVJLSVMW-UHFFFAOYAD
SMILES
  • NCCO
Properties
Chemical formula
C2H7NO
Molar mass 61.084 g·mol−1
Appearance Viscous colourless liquid
Odor Unpleasant ammonia-like odour
Density 1.0117 g/cm3
Melting point 10.3 °C (50.5 °F; 283.4 K)
Boiling point 170 °C (338 °F; 443 K)
Solubility in water
Miscible
Vapor pressure 64 Pa (20 °C)[2]
Acidity (pKa) 9.50[3]
Refractive index (nD)
1.4539 (20 °C)[4]
Hazards
GHS labelling:
Pictograms
GHS05: CorrosiveGHS07: Exclamation mark
Signal word
Danger
Hazard statements
H302, H312, H314, H332, H335, H412[5]
Precautionary statements
P261, P273, P303+P361+P353, P305+P351+P338[5]
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 3: Short exposure could cause serious temporary or residual injury. E.g. chlorine gasFlammability 2: Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur. Flash point between 38 and 93 °C (100 and 200 °F). E.g. diesel fuelInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
3
2
0
Flash point 85 °C (185 °F; 358 K) (closed cup)
Autoignition
temperature
410 °C (770 °F; 683 K)
Explosive limits 5.5–17%
Lethal dose or concentration (LD, LC):
LD50 (median dose)
  • 3320 mg/kg (rat, oral)
  • 620 mg/kg (guinea pig, oral)
  • 2050 mg/kg (rat, oral)
  • 1475 mg/kg (mouse, oral)
  • 1000 mg/kg (rabbit, oral)
  • 700 mg/kg (mouse, oral)
  • 1720–1970 mg/kg (rat, oral)[7]
NIOSH (US health exposure limits):
PEL (Permissible)
TWA: 3 ppm (6 mg/m3)[6]
REL (Recommended)
  • TWA: 3 ppm (8 mg/m3)
  • ST: 6 ppm (15 mg/m3)[6]
IDLH (Immediate danger)
30 ppm[6]
Safety data sheet (SDS) Sigma[5]
Related compounds
Related compounds
  • N-Methylethanolamine
  • Diethanolamine
  • Triethanolamine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Infobox references

Ethanolamine (2-aminoethanol, monoethanolamine, ETA, or MEA) is a naturally occurring organic chemical compound with the formula HOCH
2
CH
2
NH
2
or C
2
H
7
NO
.[8] The molecule is bifunctional, containing both a primary amine and a primary alcohol. Ethanolamine is a colorless, viscous liquid with an odor reminiscent of ammonia.[9]

Ethanolamine is commonly called monoethanolamine or MEA in order to be distinguished from diethanolamine (DEA) and triethanolamine (TEA). The ethanolamines comprise a group of amino alcohols. A class of antihistamines is identified as ethanolamines, which includes carbinoxamine, clemastine, dimenhydrinate, chlorphenoxamine, diphenhydramine and doxylamine.[10]

  1. ^ a b Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. pp. 649, 717. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4. For example, the name 'ethanolamine', which is still widely used, is badly constructed because of the presence of two suffixes; it is not an alternative to the preferred IUPAC name, '2-aminoethan-1-ol'.
  2. ^ "Ethanolamine MSDS" (PDF). Acros Organics. Archived from the original (PDF) on 2011-07-15.
  3. ^ Hall, H.K. (1957). "Correlation of the Base Strengths of Amines". J. Am. Chem. Soc. 79 (20): 5441–4. doi:10.1021/ja01577a030.
  4. ^ Reitmeier, R.E.; Sivertz, V.; Tartar, H.V. (1940). "Some Properties of Monoethanolamine and its Aqueous Solutions". Journal of the American Chemical Society. 62 (8): 1943–44. doi:10.1021/ja01865a009.
  5. ^ a b c Sigma-Aldrich Co., Ethanolamine. Retrieved on 2018-05-24.
  6. ^ a b c NIOSH Pocket Guide to Chemical Hazards. "#0256". National Institute for Occupational Safety and Health (NIOSH).
  7. ^ "Ethanolamine". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  8. ^ "National Library of Medicine. PubChem. Ethanolomine". NIH, National Library of Medicine. Retrieved September 5, 2021.
  9. ^ Martin Ernst; Johann-Peter Melder; Franz Ingo Berger; Christian Koch (2022). "Ethanolamines and Propanolamines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a10_001.pub2. ISBN 978-3527306732.
  10. ^ Cough, Cold, and Allergy Preparation Toxicity at eMedicine

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Ethanolamine

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Phosphatidylethanolamine

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membranes. They are synthesized by the addition of cytidine diphosphate-ethanolamine to diglycerides, releasing cytidine monophosphate. S-Adenosyl methionine...

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In enzymology, an ethanolamine oxidase (EC 1.4.3.8) is an enzyme that catalyzes the chemical reaction ethanolamine + H2O + O2 ⇌ {\displaystyle \rightleftharpoons...

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Virodhamine

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(O-arachidonoyl ethanolamine; O-AEA) is an endocannabinoid and a nonclassic eicosanoid, derived from arachidonic acid. O-Arachidonoyl ethanolamine is arachidonic...

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Ethanolamine kinase

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In enzymology, an ethanolamine kinase (EC 2.7.1.82) is an enzyme that catalyzes the chemical reaction ATP + ethanolamine ⇌ {\displaystyle \rightleftharpoons...

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Phosphorylethanolamine

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Phosphorylethanolamine or phosphoethanolamine is an ethanolamine derivative that is used to construct two different categories of phospholipids. One category...

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Piroctone olamine

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known as piroctone ethanolamine) is a compound sometimes used in the treatment of fungal infections. Piroctone olamine is the ethanolamine salt of the hydroxamic...

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Dimenhydrinate

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Dimenhydrinate is a theoclate salt composed of diphenhydramine (an ethanolamine derivative) and 8-chlorotheophylline (a chlorinated theophylline derivative)...

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Cocamide MEA

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fatty acids in coconut oil when reacted with ethanolamine. Cocamide MEA and other cocamide ethanolamines such as cocamide DEA are used as foaming agents...

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Dimethylethanolamine

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spatial memory and working memory. Choline Diphenhydramine Doxylamine Ethanolamine Meclofenoxate (Centrophenoxine) Orphenadrine Littel, RJ; Bos, M; Knoop...

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Diacylglycerol ethanolaminephosphotransferase

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(EC 2.7.8.1) is an enzyme that catalyzes the chemical reaction CDP-ethanolamine + 1,2-diacylglycerol ⇌ {\displaystyle \rightleftharpoons } CMP + a...

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Ethylenediamine

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Another industrial route to ethylenediamine involves the reaction of ethanolamine and ammonia: This process involves passing the gaseous reactants over...

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Alkanolamine

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Alkanolamines Methanolamine, from the reaction of ammonia with formaldehyde Ethanolamine 2-amino-2-methyl-1-propanol is a precursor to oxazolines valinol is derived...

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Alkaline copper quaternary

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in the form of a soluble complex with ammonia NH3 or an amine such as ethanolamine N(C2H5)H2. In any case, the copper content is usually expressed as a...

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Diethanolamine

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The reaction of ethylene oxide with aqueous ammonia first produces ethanolamine: C2H4O + NH3 → H2NCH2CH2OH which reacts with a second and third equivalent...

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Stearoylethanolamide

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called N-(octadecanoyl)ethanolamine, is an N-acylethanolamine and the ethanolamide of octadecanoic acid (C18H36O2; 18:0) and ethanolamine (MEA: C2H7NO), and...

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Choline

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Choline is the parent compound of the cholines class, consisting of ethanolamine residue having three methyl groups attached to the same nitrogen atom...

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Ammonia

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bloodstream, glutamine is a source of ammonia. Ethanolamine, required for cell membranes, is the substrate for ethanolamine ammonia-lyase, which produces ammonia:...

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ABCA4

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formation of toxic cationic bis-pyridinium salt, N-retinylidene-N-retinyl-ethanolamine (A2E), which causes human dry and wet age-related macular degeneration...

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