CXCL17 information

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Structures	Swiss-model
Domains	InterPro

chemokine (C-X-C motif) ligand 7
chemokine (C-X-C motif) ligand 7
Identifiers
Symbol	CXCL17
Alt. symbols	SCYB17, VCC-1, DMC
NCBI gene	284340
RefSeq	NM_198477
UniProt	Q6UXB2
Other data
Locus	Chr. 19 q13.2
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine belonging to the CXC chemokine family that has been identified in humans and mice. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors. It is also known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC).^[1]^[2] This chemokine is constitutively expressed in the lung.^[2] The gene for human CXCL17 is located on chromosome 19.^[2]

CXCL17 is an orphan chemokine with no known receptor.^[3]

^ Weinstein EJ, Head R, Griggs DW, Sun D, Evans RJ, Swearingen ML, Westlin MM, Mazzarella R (November 2006). "VCC-1, a novel chemokine, promotes tumor growth". Biochemical and Biophysical Research Communications. 350 (1): 74–81. doi:10.1016/j.bbrc.2006.08.194. PMID 16989774.
^ ^a ^b ^c Pisabarro MT, Leung B, Kwong M, Corpuz R, Frantz GD, Chiang N, Vandlen R, Diehl LJ, Skelton N, Kim HS, Eaton D, Schmidt KN (February 2006). "Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods". Journal of Immunology. 176 (4): 2069–73. doi:10.4049/jimmunol.176.4.2069. PMID 16455961.
^ Binti Mohd Amir NA, Mackenzie AE, Jenkins L, Boustani K, Hillier MC, Tsuchiya T, Milligan G, Pease JE (June 2018). "Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35". Journal of Immunology. 201 (2): 714–724. doi:10.4049/jimmunol.1700884. PMC 6036231. PMID 29875152.

[1] Weinstein EJ, Head R, Griggs DW, Sun D, Evans RJ, Swearingen ML, Westlin MM, Mazzarella R (November 2006). "VCC-1, a novel chemokine, promotes tumor growth". Biochemical and Biophysical Research Communications. 350 (1): 74–81. doi:10.1016/j.bbrc.2006.08.194. PMID 16989774.

[pisa-2] Pisabarro MT, Leung B, Kwong M, Corpuz R, Frantz GD, Chiang N, Vandlen R, Diehl LJ, Skelton N, Kim HS, Eaton D, Schmidt KN (February 2006). "Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods". Journal of Immunology. 176 (4): 2069–73. doi:10.4049/jimmunol.176.4.2069. PMID 16455961.

[:0-3] Binti Mohd Amir NA, Mackenzie AE, Jenkins L, Boustani K, Hillier MC, Tsuchiya T, Milligan G, Pease JE (June 2018). "Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35". Journal of Immunology. 201 (2): 714–724. doi:10.4049/jimmunol.1700884. PMC 6036231. PMID 29875152.

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