CCL19 information

CCL19
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2MP1
Identifiers
Aliases	CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19, C-C motif chemokine ligand 19
External IDs	OMIM: 602227; MGI: 5434459; HomoloGene: 4569; GeneCards: CCL19; OMA:CCL19 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	34,691,276 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	42,072,779 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; gallbladder; ; thymus; ; rectum; ; left coronary artery; ; right coronary artery; ; thymus; ; gastric mucosa; ; right lobe of thyroid gland;
	Top expressed in
	spleen; ; adrenal gland; ; superior frontal gyrus; ; thymus; ; lip; ; zone of skin; ; kidney; ; islet of Langerhans; ; cerebellar cortex; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	CCR10 chemokine receptor binding; cytokine activity; chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity; CCR chemokine receptor binding; protein binding;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	release of sequestered calcium ion into cytosol; positive regulation of receptor-mediated endocytosis; positive regulation of protein kinase B signaling; positive regulation of cell motility; positive regulation of dendritic cell dendrite assembly; positive regulation of interleukin-12 production; regulation of cell projection assembly; monocyte chemotaxis; positive regulation of T-helper 1 cell differentiation; chemokine-mediated signaling pathway; response to nitric oxide; cellular response to tumor necrosis factor; T cell costimulation; response to virus; cellular calcium ion homeostasis; cell maturation; myeloid dendritic cell chemotaxis; positive regulation of JNK cascade; dendritic cell chemotaxis; positive regulation of phosphatidylinositol 3-kinase activity; chemotaxis; cell communication; positive regulation of endocytosis; positive regulation of GTPase activity; response to prostaglandin E; positive regulation of dendritic cell antigen processing and presentation; positive regulation of chemotaxis; cellular response to interleukin-1; positive regulation of T cell proliferation; immune response; positive regulation of ERK1 and ERK2 cascade; establishment of T cell polarity; positive regulation of glycoprotein biosynthetic process; cellular response to interferon-gamma; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; lymphocyte chemotaxis; positive regulation of neutrophil chemotaxis; inflammatory response; immunological synapse formation; mature conventional dendritic cell differentiation; positive regulation of protein kinase activity; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; negative regulation of dendritic cell apoptotic process; cytokine-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; neutrophil chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6363
	100861647
	ENSG00000172724
	ENSMUSG00000118633
	Q99731
	n/a
	NM_006274
	XM_006538413
	NP_006265
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.^[5]^[6]

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.^[6]

Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.^[7] The gene for CCL19 is located on human chromosome 9.^[8] This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7.^[7] It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells,^[9]^[10] CCR7+ central-memory T-Cells.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172724 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000118633 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J Biol Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
^ ^a ^b "Entrez Gene: CCL19 chemokine (C-C motif) ligand 19".
^ ^a ^b Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
^ Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. doi:10.4049/jimmunol.158.3.1033. PMID 9013939. S2CID 39291729.
^ Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes". Cell. 103 (5): 757–68. doi:10.1016/S0092-8674(00)00179-3. PMID 11114332. S2CID 15592251.
^ Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position". Nature. 416 (6876): 94–9. Bibcode:2002Natur.416...94R. doi:10.1038/416094a. PMID 11882900. S2CID 4403093.
^ Bromley SK, Thomas SY, Luster AD (2005). "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics". Nat. Immunol. 6 (9): 895–901. doi:10.1038/ni1240. PMID 16116469. S2CID 443455.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172724 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000118633 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9153236-5] Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J Biol Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.

[entrez-6] "Entrez Gene: CCL19 chemokine (C-C motif) ligand 19".

[Yoshida_1997-7] Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.

[pmid9013939-8] Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. doi:10.4049/jimmunol.158.3.1033. PMID 9013939. S2CID 39291729.

[pmid11114332-9] Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes". Cell. 103 (5): 757–68. doi:10.1016/S0092-8674(00)00179-3. PMID 11114332. S2CID 15592251.

[pmid11882900-10] Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position". Nature. 416 (6876): 94–9. Bibcode:2002Natur.416...94R. doi:10.1038/416094a. PMID 11882900. S2CID 4403093.

[pmid16116469-11] Bromley SK, Thomas SY, Luster AD (2005). "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics". Nat. Immunol. 6 (9): 895–901. doi:10.1038/ni1240. PMID 16116469. S2CID 443455.

CCL19 information

and 28 Related for: CCL19 information

CCL19

Chemokine

Macrophage inflammatory protein

Haematopoiesis

Tumor necrosis factor

Cytokine

Interferon

Ubiquitin

CC chemokine receptors

CCRL1

Tumor necrosis factor superfamily

Transfer factor

ELC

Interleukin 17

Interleukin 23

Interleukin 1 beta

CXCR4

Myokine

Interleukin 12

Inflammatory cytokine

Interferon type I

List of distinct cell types in the adult human body

Interleukin 6

Interleukin 8

Interleukin

K562 cells

Interleukin 2

Interleukin 10