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CC chemokine receptors information


CCR1
Identifiers
SymbolCCR1
NCBI gene1230
HGNC1602
OMIM601159
RefSeqNM_001295
UniProtP32246
Other data
LocusChr. 3 p21
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StructuresSwiss-model
DomainsInterPro
CCR2
Identifiers
SymbolCCR2
NCBI gene1231
HGNC1603
OMIM601268
PDB1KAD
RefSeqNM_000647
UniProtP41597
Other data
LocusChr. 3 p21
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StructuresSwiss-model
DomainsInterPro
CCR3
Identifiers
SymbolCCR3
NCBI gene1232
HGNC1604
OMIM601268
RefSeqNM_001837
UniProtP51677
Other data
LocusChr. 3 p21
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StructuresSwiss-model
DomainsInterPro
CCR4
Identifiers
SymbolCCR4
NCBI gene1233
HGNC1605
OMIM604836
RefSeqNM_005508
UniProtP51679
Other data
LocusChr. 3 p24
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StructuresSwiss-model
DomainsInterPro
CCR5
Identifiers
SymbolCCR5
NCBI gene1234
HGNC1606
OMIM601373
PDB1ND8
RefSeqNM_000579
UniProtP51681
Other data
LocusChr. 3 p21
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StructuresSwiss-model
DomainsInterPro
CCR6
Identifiers
SymbolCCR6
NCBI gene1235
HGNC1607
OMIM601835
RefSeqNM_004367
UniProtP51684
Other data
LocusChr. 6 q27
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StructuresSwiss-model
DomainsInterPro
CCR7
Identifiers
SymbolCCR7
NCBI gene1236
HGNC1608
OMIM600242
RefSeqNM_001838
UniProtP32248
Other data
LocusChr. 17 q12-q21.2
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StructuresSwiss-model
DomainsInterPro
CCR8
Identifiers
SymbolCCR8
NCBI gene1237
HGNC1609
OMIM601834
RefSeqNM_005201
UniProtP51685
Other data
LocusChr. 3 p22
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StructuresSwiss-model
DomainsInterPro
CCR9
Identifiers
SymbolCCR9
NCBI gene10803
HGNC1610
OMIM604738
RefSeqNM_031200
UniProtP51686
Other data
LocusChr. 3 p21
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StructuresSwiss-model
DomainsInterPro
CCR10
Identifiers
SymbolCCR10
NCBI gene2826
HGNC4474
OMIM600240
RefSeqNM_016602
UniProtP46092
Other data
LocusChr. 17 17q21.1-q21
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StructuresSwiss-model
DomainsInterPro

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

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CC chemokine receptors

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CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine...

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Chemokine receptor

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Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors...

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CXC chemokine receptors

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chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM)...

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Chemokine

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CC, CX3C and C. All of these proteins exert their biological effects by interacting with G protein-linked transmembrane receptors called chemokine receptors...

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CCR2

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C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. CCR2 is a CC chemokine...

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CCR1

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encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha)...

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CCR4

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CCR4+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "Chemokine Receptors: CCR4". IUPHAR Database of Receptors and Ion...

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CCL7

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monocyte-chemotactic protein 3 (MCP3). CCL7 is a small protein that belongs to the CC chemokine family and is most closely related to CCL2 (previously called MCP1)....

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CCR5

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beta chemokine receptors family of integral membrane proteins. It is a G protein–coupled receptor which functions as a chemokine receptor in the CC chemokine...

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CCL21

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Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has...

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CCL5

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clunky acronym was only made to fit the name. CCL5 belongs to the CC subfamily of chemokines, due to its adjacent cysteines near N terminus. It is an 8kDa...

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CCR9

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the beta chemokine receptor family. CCR9 is a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors, such as...

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CX3C motif chemokine receptor 1

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CX3C motif chemokine receptor 1 (CX3CR1), also known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13), is a transmembrane protein...

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CCR10

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acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28. This receptor is normally expressed...

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CCL22

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cell surface chemokine receptors such as CCR4. The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1...

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CXCR4

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C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4...

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CCL13

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through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626 Naruse et al., A YAC contig of the human CC chemokine genes clustered...

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Eotaxin

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The eotaxins are a CC chemokine subfamily of eosinophil chemotactic proteins. Eotaxin is a special CC chemokine because it primarily attracts eosinophils...

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CCBP2

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seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment...

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CCL4

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inflammatory properties. CCL4 is a small cytokine that belongs to the CC chemokine subfamily. CCL4 is being secreted under mitogenic signals and antigens...

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Interleukin 8

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Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...

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CCL18

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Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family. The functions of CCL18 have been well studied in laboratory...

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CCL3L1

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Specifically, chemokines attract lymphocytes to sites of infection or damage. This protein binds to several chemokine receptors including chemokine binding...

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Cytokine receptor

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Cytokine receptors are receptors that bind to cytokines. In recent years, the cytokine receptors have come to demand the attention of more investigators...

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Mogamulizumab

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Poteligeo, is a humanized, afucosylated monoclonal antibody targeting CC chemokine receptor type 4 (CCR4). It is given by injection into a vein. The most common...

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