BARD1 information

BARD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JM7, 2NTE, 2R1Z, 3C5R, 3FA2
Identifiers
Aliases	BARD1, BRCA1 associated RING domain 1
External IDs	OMIM: 601593 MGI: 1328361 HomoloGene: 400 GeneCards: BARD1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	214,809,683 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	71,142,305 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; nipple; ; Achilles tendon; ; saphenous vein; ; human penis; ; bone marrow; ; trabecular bone; ; amniotic fluid; ; oral cavity; ; vena cava;
	Top expressed in
	secondary oocyte; ; urethra; ; spermatocyte; ; male urethra; ; morula; ; yolk sac; ; spermatid; ; thymus; ; lip; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein homodimerization activity; kinase binding; RNA binding; protein heterodimerization activity; ubiquitin-protein transferase activity; protein binding; transferase activity;
Cellular component	cytoplasm; BRCA1-A complex; BRCA1-BARD1 complex; ubiquitin ligase complex; nucleus; nucleoplasm; nuclear speck; cytoplasmic ribonucleoprotein granule;
Biological process	regulation of phosphorylation; negative regulation of apoptotic process; protein K6-linked ubiquitination; negative regulation of mRNA 3'-end processing; positive regulation of protein catabolic process; negative regulation of protein export from nucleus; double-strand break repair via nonhomologous end joining; cellular response to DNA damage stimulus; tissue homeostasis; protein ubiquitination; positive regulation of apoptotic process; DNA replication; DNA double-strand break processing; DNA repair; protein deubiquitination; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	580
	12021
	ENSG00000138376
	ENSMUSG00000026196
	Q99728
	O70445
	NM_000465; NM_001282543; NM_001282545; NM_001282548; NM_001282549
	NM_007525
NP_000456; NP_001269472; NP_001269474; NP_001269477; NP_001269478;
	NP_001269474.1
	NP_031551
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene.^[5]^[6]^[7] The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and two tandem BRCT domains (residues 568-777).^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026196 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, Xu XL, Yang MC, Hwang LY, Bowcock AM, Baer R (Dec 1996). "Identification of a RING protein that can interact in vivo with the BRCA1 gene product". Nature Genetics. 14 (4): 430–40. doi:10.1038/ng1296-430. PMID 8944023. S2CID 22728511.
^ Thai TH, Du F, Tsan JT, Jin Y, Phung A, Spillman MA, Massa HF, Muller CY, Ashfaq R, Mathis JM, Miller DS, Trask BJ, Baer R, Bowcock AM (Feb 1998). "Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers". Human Molecular Genetics. 7 (2): 195–202. doi:10.1093/hmg/7.2.195. PMID 9425226.
^ Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK (Jul 2004). "BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage". The Journal of Biological Chemistry. 279 (30): 31251–8. doi:10.1074/jbc.M405372200. PMID 15159397.
^ Cite error: The named reference ReferenceB was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138376 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026196 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8944023-5] Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, Xu XL, Yang MC, Hwang LY, Bowcock AM, Baer R (Dec 1996). "Identification of a RING protein that can interact in vivo with the BRCA1 gene product". Nature Genetics. 14 (4): 430–40. doi:10.1038/ng1296-430. PMID 8944023. S2CID 22728511.

[pmid9425226-6] Thai TH, Du F, Tsan JT, Jin Y, Phung A, Spillman MA, Massa HF, Muller CY, Ashfaq R, Mathis JM, Miller DS, Trask BJ, Baer R, Bowcock AM (Feb 1998). "Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers". Human Molecular Genetics. 7 (2): 195–202. doi:10.1093/hmg/7.2.195. PMID 9425226.

[pmid15159397-7] Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK (Jul 2004). "BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage". The Journal of Biological Chemistry. 279 (30): 31251–8. doi:10.1074/jbc.M405372200. PMID 15159397.

[ReferenceB-8] Cite error: The named reference ReferenceB was invoked but never defined (see the help page).

BARD1 information

and 27 Related for: BARD1 information

BARD1

BRCA1

CSTF1

H2AFX

CSTF2

Loss of heterozygosity

Ubiquitin

P53

BRCA2

Multifactorial disease

UBE2D1

E2F

Topoisomerase

RING finger domain

Xenopus

Histone H2A

BRCT domain

BAP1

NPM1

RAD51

Aurora kinase B

Ankyrin repeat

MED17

Center for Applied Genomics

BCL3

TACC1

DGLUCY