CSTF1 information

CSTF1
Identifiers
Aliases	CSTF1, CstF-50, CstFp50, cleavage stimulation factor subunit 1
External IDs	OMIM: 600369; MGI: 1914587; HomoloGene: 1012; GeneCards: CSTF1; OMA:CSTF1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	56,406,362 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	172,224,368 bp
RNA expression pattern
	Top expressed in
	testicle; ; secondary oocyte; ; Achilles tendon; ; gonad; ; islet of Langerhans; ; stromal cell of endometrium; ; ventricular zone; ; rectum; ; granulocyte; ; body of pancreas;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; yolk sac; ; epiblast; ; ventricular zone; ; secondary oocyte; ; Ileal epithelium; ; tail of embryo; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	nucleus; nucleoplasm; mRNA cleavage stimulating factor complex;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	1477
	67337
	ENSG00000101138
	ENSMUSG00000027498
	Q05048
	Q99LC2
	NM_001033521; NM_001033522; NM_001324
	NM_024199
	NP_001028693; NP_001028694; NP_001315
	NP_077161
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.^[5]^[6]^[7]

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101138 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027498 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takagaki Y, Manley JL (November 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". The Journal of Biological Chemistry. 267 (33): 23471–4. doi:10.1016/S0021-9258(18)35861-7. PMID 1358884.
^ Kleiman FE, Manley JL (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228. S2CID 15022237.
^ ^a ^b "Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101138 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027498 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1358884-5] Takagaki Y, Manley JL (November 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". The Journal of Biological Chemistry. 267 (33): 23471–4. doi:10.1016/S0021-9258(18)35861-7. PMID 1358884.

[pmid11257228-6] Kleiman FE, Manley JL (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228. S2CID 15022237.

[entrez-7] "Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa".

CSTF1 information

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