NPM1 information

NPM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LLH, 2P1B, 2VXD
Identifiers
Aliases	NPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 1
External IDs	OMIM: 164040; MGI: 106184; HomoloGene: 81697; GeneCards: NPM1; OMA:NPM1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	171,411,810 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	33,113,206 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; left ovary; ; ventricular zone; ; right ovary; ; canal of the cervix; ; body of uterus; ; ganglionic eminence; ; body of pancreas; ; right uterine tube; ; ectocervix;
	Top expressed in
	tail of embryo; ; epiblast; ; genital tubercle; ; morula; ; embryo; ; primary oocyte; ; zygote; ; secondary oocyte; ; embryo; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribosomal large subunit binding; protein homodimerization activity; ribosomal small subunit binding; unfolded protein binding; transcription coactivator activity; protein kinase inhibitor activity; histone binding; Tat protein binding; NF-kappaB binding; protein binding; RNA binding; protein heterodimerization activity; nucleic acid binding; protein kinase binding; transcription factor binding; rRNA binding; protein N-terminus binding; chromatin binding;
Cellular component	cytoplasm; membrane; focal adhesion; spindle pole centrosome; nucleoplasm; microtubule organizing center; nucleolus; cytoskeleton; nucleus; protein-DNA complex; granular component; centrosome; cytosol; large ribosomal subunit; small ribosomal subunit; nuclear speck; protein-containing complex; ribonucleoprotein complex;
Biological process	centrosome cycle; regulation of eIF2 alpha phosphorylation by dsRNA; positive regulation of cell cycle G2/M phase transition; negative regulation of centrosome duplication; regulation of centriole replication; response to stress; positive regulation of translation; CENP-A containing chromatin assembly; positive regulation of transcription, DNA-templated; positive regulation of NF-kappaB transcription factor activity; protein complex oligomerization; negative regulation of protein kinase activity by regulation of protein phosphorylation; regulation of endodeoxyribonuclease activity; regulation of endoribonuclease activity; ribosome assembly; intracellular protein transport; DNA repair; signal transduction; negative regulation of cell population proliferation; nucleosome assembly; viral process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of transcription by RNA polymerase II; cellular response to UV; ribosomal large subunit export from nucleus; ribosomal small subunit export from nucleus; rRNA export from nucleus; cell volume homeostasis; nucleocytoplasmic transport; protein localization; positive regulation of cell population proliferation; posttranscriptional regulation of gene expression; negative regulation of gene expression; regulation of centrosome duplication; positive regulation of centrosome duplication; cell growth; positive regulation of cellular biosynthetic process; positive regulation of protein ubiquitination; regulation of protein stability; ribosomal large subunit biogenesis; ribosomal small subunit biogenesis; negative regulation of apoptotic process; regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; negative regulation of mRNA splicing, via spliceosome; protein stabilization; protein homooligomerization; regulation of cell cycle; positive regulation of protein localization to nucleolus; chromatin remodeling; regulation of mRNA stability involved in cellular response to UV;
	Sources:Amigo / QuickGO
Orthologs
	4869
	18148
	ENSG00000181163
	ENSMUSG00000057113
	P06748
	Q61937
NM_001037738; NM_002520; NM_199185; NM_001355006; NM_001355009;
	NM_001355007; NM_001355010
	NM_001252260; NM_001252261; NM_008722
NP_001032827; NP_002511; NP_954654; NP_001341935; NP_001341938;
	NP_001341936; NP_001341939
	NP_001239189; NP_001239190; NP_032748
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181163 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057113 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu QR, Chan PK (March 1993). "Characterization of seven processed pseudogenes of nucleophosmin/B23 in the human genome". DNA and Cell Biology. 12 (2): 149–156. doi:10.1089/dna.1993.12.149. PMID 8471164.
^ Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–1284. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181163 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057113 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8471164-5] Liu QR, Chan PK (March 1993). "Characterization of seven processed pseudogenes of nucleophosmin/B23 in the human genome". DNA and Cell Biology. 12 (2): 149–156. doi:10.1089/dna.1993.12.149. PMID 8471164.

[pmid8122112-6] Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–1284. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.

NPM1 information

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