E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the TTTCCCGC (or slight variations of this sequence) consensus binding site in the target promoter sequence.
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six...
for E2F 4 and E2F 5, which work to repress transcription of G1-to-S promoting factors. The third pocket protein, Rb, binds to and represses E2F 1, E2F 2...
E2F/DP1/Rb complex (which was bound to the E2F responsive genes, effectively "blocking" them from transcription), activating E2F. Activation of E2F results...
repression of the E2F family of transcription factors regulates the G0 to G1 transition just as it does the G1 to S transition. Activating E2F complexes are...
Hyperphosphorylated pRb can no longer bind E2F, E2F is released and cyclin A genes, and other crucial genes for S phase, are transcribed. E2F initiates transcription of...
DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma...
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle...
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle...
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex is a protein complex responsible for the regulation of cell cycle-dependent...
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle...
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle...
(Oct 2003). "Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation". J Biol Chem. 278...
methods of preventing Cdk activity are found in G1 phase: pRB binding to E2F family transcription factors downregulate expression of S phase cyclin genes;...
Unphosphorylated Rb acts as an inhibitor of G1 by preventing E2F-mediated transcription. Once phosphorylated, E2F activates the transcription of cyclins E and A. Active...
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle...
factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene. The E2F transcription factor family (see MIM 189971) regulates the expression of...
activated by E2F transcription factors that were shown to be required for endoreduplication. Recent work suggests that observed oscillations in E2F and cyclin...
release of E2F transcription factor, which in turn initiates expression of S-phase genes. Several E2F target genes promote further release of E2F, creating...
in turn, halting cell cycle progression by preventing the activation of E2F. In short, p53 is a tumor-suppressor protein that arrests the cell cycle...
phosphorylate the Retinoblastoma (Rb) protein, a tumor suppressor bound with the E2F family of transcription factors. The binding of this Rb protein ensures that...
protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle...
inactive, which through a downstream signalling cascade allows the release of E2F and thus, progression through the Restriction point (R point) in G1 phase...
principally arises from binding and inactivation of the transcription factor E2F, thus repressing the transcription of genes which are required for the S...
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