BCL3 information

BCL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K1A, 1K1B
Identifiers
Aliases	BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, transcription coactivator, BCL3 transcription coactivator
External IDs	OMIM: 109560; MGI: 88140; HomoloGene: 81738; GeneCards: BCL3; OMA:BCL3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,760,044 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,556,695 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; right lobe of liver; ; upper lobe of left lung; ; gastric mucosa; ; mucosa of transverse colon; ; spleen; ; apex of heart; ; olfactory zone of nasal mucosa; ; left adrenal cortex; ; right lung;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; mesenteric lymph nodes; ; intestinal villus; ; jejunum; ; left lobe of liver; ; duodenum; ; colon; ; ileum; ; ankle joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein-macromolecule adaptor activity; DNA-binding transcription factor activity; transcription factor binding; protein binding;
Cellular component	cytoplasm; Bcl3-Bcl10 complex; nucleoplasm; perinuclear region of cytoplasm; Bcl3/NF-kappaB2 complex; nucleus; cytosol; plasma membrane; midbody; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	regulation of apoptotic process; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; regulation of DNA binding; regulation of transcription, DNA-templated; T-helper 2 cell differentiation; antimicrobial humoral response; germinal center formation; response to virus; DNA damage response, signal transduction by p53 class mediator; extracellular matrix organization; positive regulation of interferon-gamma production; negative regulation of apoptotic process; spleen development; marginal zone B cell differentiation; positive regulation of translation; transcription, DNA-templated; cellular response to DNA damage stimulus; positive regulation of transcription, DNA-templated; humoral immune response mediated by circulating immunoglobulin; follicular dendritic cell differentiation; defense response to bacterium; T-helper 1 type immune response; negative regulation of transcription, DNA-templated; I-kappaB kinase/NF-kappaB signaling; response to UV-C; maintenance of protein location in nucleus; positive regulation of transcription by RNA polymerase II; defense response to protozoan; negative regulation of receptor signaling pathway via JAK-STAT; regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	602
	12051
	ENSG00000069399
	ENSMUSG00000053175
	P20749
	Q9Z2F6
	NM_005178
	NM_033601
	NP_005169
	NP_291079
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.^[5]^[6]

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.^[7]

Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069399 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053175 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wulczyn FG, Naumann M, Scheidereit C (August 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): 597–599. Bibcode:1992Natur.358..597W. doi:10.1038/358597a0. PMID 1501714. S2CID 4363340.
^ Ohno H, Takimoto G, McKeithan TW (March 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell. 60 (6): 991–997. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. S2CID 1919787.
^ "Entrez Gene: BCL3 B-cell CLL/lymphoma 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069399 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053175 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1501714-5] Wulczyn FG, Naumann M, Scheidereit C (August 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): 597–599. Bibcode:1992Natur.358..597W. doi:10.1038/358597a0. PMID 1501714. S2CID 4363340.

[pmid2180580-6] Ohno H, Takimoto G, McKeithan TW (March 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell. 60 (6): 991–997. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. S2CID 1919787.

[entrez-7] "Entrez Gene: BCL3 B-cell CLL/lymphoma 3".

BCL3 information

and 25 Related for: BCL3 information

Boron trichloride

BCL3

Boron trifluoride

Tetrahydroxydiboron

Tetranitratoborate

Aluminium

Boron

Diboron tetrachloride

Chlorine

Diborane

Hydrogen chloride

Bromopentafluorobenzene

Borosilicate glass

Arsine

List of CAS numbers by chemical compound

Hypochlorous acid

Boron trifluoride etherate

Borazine

Boric acid

Lewis acids and bases

Glossary of chemical formulae

Bromine

Chlorine trifluoride

Xenon dichloride

Nitrogen trichloride