MED17 information

MED17
Identifiers
Aliases	MED17, CRSP6, CRSP77, DRIP80, TRAP80, mediator complex subunit 17, SRB4
External IDs	OMIM: 603810; MGI: 2182585; HomoloGene: 3151; GeneCards: MED17; OMA:MED17 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	93,814,963 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	15,191,227 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; left ovary; ; right ovary; ; canal of the cervix; ; stromal cell of endometrium; ; granulocyte; ; body of uterus;
	Top expressed in
	primary oocyte; ; granulocyte; ; zygote; ; secondary oocyte; ; epiblast; ; ventricular zone; ; morula; ; endocardial cushion; ; abdominal wall; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coregulator activity; thyroid hormone receptor binding; protein binding; nuclear receptor coactivator activity; vitamin D receptor binding; transcription coactivator activity; signaling receptor activity; ubiquitin protein ligase activity;
Cellular component	membrane; transcription regulator complex; nucleoplasm; mediator complex; nucleus; core mediator complex; ubiquitin ligase complex;
Biological process	androgen receptor signaling pathway; regulation of transcription, DNA-templated; intracellular steroid hormone receptor signaling pathway; transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; protein ubiquitination; stem cell population maintenance;
	Sources:Amigo / QuickGO
Orthologs
	9440
	234959
	ENSG00000042429
	ENSMUSG00000031935
	Q9NVC6
	Q8VCD5
	NM_004268
	NM_144933; NM_001364533
	NP_004259
	NP_659182; NP_001351462
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.^[5]^[6]^[7]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000042429 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031935 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. hdl:11858/00-001M-0000-0019-A36A-8. PMID 9989412. S2CID 4405569.
^ Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
^ ^a ^b "Entrez Gene: CRSP6 cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000042429 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031935 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9989412-5] Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. hdl:11858/00-001M-0000-0019-A36A-8. PMID 9989412. S2CID 4405569.

[pmid10198638-6] Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.

[entrez-7] "Entrez Gene: CRSP6 cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa".

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