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CSTF2 information


CSTF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSTF2, CstF-64, cleavage stimulation factor subunit 2
External IDsOMIM: 300907; MGI: 1343054; HomoloGene: 80171; GeneCards: CSTF2; OMA:CSTF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001306206
NM_001306209
NM_001325

NM_001290398
NM_001290399
NM_133196
NM_001359053
NM_001359054

RefSeq (protein)

NP_001293135
NP_001293138
NP_001316
NP_001293135.1

NP_001277327
NP_001277328
NP_573459
NP_001345982
NP_001345983

Location (UCSC)Chr X: 100.82 – 100.84 MbChr X: 132.96 – 132.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.[5][6]

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101811 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031256 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A. 89 (4): 1403–7. Bibcode:1992PNAS...89.1403T. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.
  6. ^ a b "Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa".

and 9 Related for: CSTF2 information

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CSTF2

Last Update:

stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene. This gene encodes a nuclear protein with an RRM (RNA recognition motif)...

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Cleavage stimulation factor

Last Update:

CStF) is a heterotrimeric protein, made up of the proteins CSTF1 (55kDa), CSTF2 (64kDa) and CSTF3 (77kDa), totalling about 200 kDa. It is involved in the...

Word Count : 249

CSTF3

Last Update:

The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation...

Word Count : 812

BRCA1

Last Update:

BACH1 BARD1 BRCA2 BRCC3 BRE BRIP1 C-jun CHEK2 CLSPN COBRA1 CREBBP CSNK2B CSTF2 CDK2 DHX9 ELK4 EP300 ESR1 FANCA FANCD2 FHL2 H2AFX JUNB JunD LMO4 MAP3K3...

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Cleavage and polyadenylation specificity factor

Last Update:

(CstF) has three subunits: CstF77 (CstF3), CstF50 (CstF1), and CstF64 (CstF2 and CstF2T). CstF recognizes the PAS that is 20 nucleotides downstream the...

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RNA recognition motif

Last Update:

BRUNOL5; BRUNOL6; CCBL2; CGI-96; CIRBP; CNOT4; CPEB2; CPEB3; CPEB4; CPSF7; CSTF2; CSTF2T; CUGBP1; CUGBP2; D10S102; DAZ1; DAZ2; DAZ3; DAZ4; DAZAP1; DAZL;...

Word Count : 812

SYMPK

Last Update:

tight junctions in some cell types. SYMPK has been shown to interact with CSTF2, HSF1 and Oct4 GRCh38: Ensembl release 89: ENSG00000125755 – Ensembl, May...

Word Count : 898

SUB1

Last Update:

repair of DNA double-strand breaks. SUB1 has been shown to interact with CSTF2. GRCh38: Ensembl release 89: ENSG00000113387 – Ensembl, May 2017 GRCm38:...

Word Count : 1179

BARD1

Last Update:

been shown to interact with: AURKB, BCL3, BRCA1, BRCA2, BRCC3, BRE, CSTF1, CSTF2, EWSR1, FANCD2, H2AFX, NPM1, P53, RAD51, TACC1, and UBE2D1. If a cancer...

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