Multifactorial diseases are not confined to any specific pattern of single gene inheritance and are likely to be caused when multiple genes come together along with the effects of environmental factors.[1]
In fact, the terms 'multifactorial' and 'polygenic' are used as synonyms and these terms are commonly used to describe the architecture of disease causing genetic component.[2] Multifactorial diseases are often found gathered in families yet, they do not show any distinct pattern of inheritance. It is difficult to study and treat multifactorial diseases because specific factors associated with these diseases have not yet been identified. Some common multifactorial disorders include schizophrenia, diabetes, asthma, depression, high blood pressure, Alzheimer's, obesity, epilepsy, heart diseases, Hypothyroidism, club foot, cancer, birth defects and even dandruff.
The multifactorial threshold model[3] assumes that gene defects for multifactorial traits are usually distributed within populations. Firstly, different populations might have different thresholds. This is the case in which occurrences of a particular disease is different in males and females (e.g. Pyloric stenosis). The distribution of susceptibility is the same but threshold is different. Secondly, threshold may be same but the distributions of susceptibility may be different. It explains the underlying risks present in first degree relatives of affected individuals.
^Duarte, Christine W.; Vaughan, Laura K.; Beasley, T. Mark; Tiwari, Hemant K. (2013), "Multifactorial Inheritance and Complex Diseases", Emery and Rimoin's Principles and Practice of Medical Genetics, Elsevier, pp. 1–15, doi:10.1016/b978-0-12-383834-6.00014-8, ISBN 978-0-12-383834-6, S2CID 160734530
^Plomin, Robert; Haworth, Claire M. A.; Davis, Oliver S. P. (2009-10-27). "Common disorders are quantitative traits". Nature Reviews Genetics. 10 (12): 872–878. doi:10.1038/nrg2670. ISSN 1471-0056. PMID 19859063. S2CID 13789104.
Multifactorialdiseases are not confined to any specific pattern of single gene inheritance and are likely to be caused when multiple genes come together...
Ischaemic heart disease Psoriasis Schizophrenia Thyroid diseasesMultifactorially inherited diseases are said to constitute the majority of genetic disorders...
pattern of predisposition for a disease process. This disambiguation page lists articles associated with the title Multifactorial. If an internal link led you...
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microbiota that, in turn, elicit further immune responses. IBD is a multifactorialdisease that is nonetheless driven in part by an exaggerated immune response...
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be referred to as having a multifactorial pattern. There are many different types of environmental disease including: Disease caused by physical factors...
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be multifactorial, both in that more than one genetic factor can cause the disease and in that more than one factor is necessary for the disease to manifest...
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infectious DNA clones. Therefore, it is assumed that PMWS is a multifactorialdisease. PCV-2 is necessary but not sufficient for the development of PMWS...
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