negative regulation of cell population proliferation
proteolysis
regulation of cell growth
monoubiquitinated protein deubiquitination
positive regulation of protein targeting to mitochondrion
protein K48-linked deubiquitination
monoubiquitinated histone H2A deubiquitination
response to inorganic substance
protein deubiquitination
regulation of inflammatory response
macrophage homeostasis
regulation of cytokine production involved in inflammatory response
chromatin organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8314
104416
Ensembl
ENSG00000163930
ENSMUSG00000021901
UniProt
Q92560
Q99PU7
RefSeq (mRNA)
NM_004656
NM_027088
RefSeq (protein)
NP_004647
NP_081364
Location (UCSC)
Chr 3: 52.4 – 52.41 Mb
Chr 14: 30.97 – 30.98 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene.[5][6]BAP1 encodes an 80.4 kDa nuclear-localizing protein with a ubiquitin carboxy-terminal hydrolase (UCH) domain that gives BAP1 its deubiquitinase activity.[5] Recent studies have shown that BAP1 and its fruit fly homolog, Calypso, are members of the polycomb-group proteins (PcG) of highly conserved transcriptional repressors required for long-term silencing of genes that regulate cell fate determination, stem cell pluripotency, and other developmental processes.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000163930 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021901 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abJensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA, Ishov AM, Tommerup N, Vissing H, Sekido Y, Minna J, Borodovsky A, Schultz DC, Wilkinson KD, Maul GG, Barlev N, Berger SL, Prendergast GC, Rauscher FJ (Mar 1998). "BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression". Oncogene. 16 (9): 1097–112. doi:10.1038/sj.onc.1201861. PMID 9528852. S2CID 1019611.
by the BAP1 gene. BAP1 encodes an 80.4 kDa nuclear-localizing protein with a ubiquitin carboxy-terminal hydrolase (UCH) domain that gives BAP1 its deubiquitinase...
tumor stage or later metastatic spread. In contrast, mutations in the gene BAP1 are strongly linked to metastatic spread and patient survival. Incidence...
population in 2012, it was found that people with a germline mutation in their BAP1 gene are at higher risk of developing mesothelioma and uveal melanoma. Erionite...
activity. BRCA1 could form dimer with other molecules, such as BARD1 and BAP1, for its ubiquitylation activity. Mutations that affect the ligase function...
prognosis, Wnt-altered subtype Cholangiocarcinoma 38 Low expression of CDKN2, BAP1, and ARID1 genes and overexpression of FGFR2 and IDH1/2 genes; four subtypes...
Milot E, Shi Y, Affar el B (Nov 2010). "The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of...
Drobetsky E, Milot E, Shi Y, Affar EB., The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY! and HCF-1 and is a critical regulator of...
identified to be associated with metastasis in uveal melanomas. Moreover BAP1, GNAQ, GNA11, SF3B1 and EIF1AX gene alterations were shown to be in correlation...
mesothelioma biologist whose team cloned AKT genes and co-discovered the BAP1 tumor predisposition syndrome Eeva Therman (1916–2004), Finnish-born US geneticist...
They are negative for MOC31, BerEP4, and vascular markers (CD31 or CD34). BAP1 expression is retained. L1 cell adhesion molecule (L1CAM), a marker of NF-kB...
metastasis. Moreover, mutation of gene involved in chromatin remodeling (SETD2, BAP1, or PBRM) may lead to higher rate of TFE3/TFEB fusion. Additionally, CIMP...
N, Do QN, et al. (August 2017). "Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade". Cancer Discovery. 7 (8): 900–917...
(ATXN3, ATXN3L) the ubiquitin C-terminal hydrolase (UCH) superfamily; (BAP1, UCHL1, UCHL3, UCHL5) the MINDY family of K48-specific deubiquitinases; (MINDY1...
M.; Brewster, Ryan; Bi, Wenya Linda (2017-04-01). "Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas". Neuro-Oncology. 19 (4): 535–545...
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