UBE2D1 information

UBE2D1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C4P, 2YHO, 3OJ4, 3PTF, 4AP4, 4QPL, 5FER
Identifiers
Aliases	UBE2D1, E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A, ubiquitin conjugating enzyme E2 D1
External IDs	OMIM: 602961; MGI: 2384911; HomoloGene: 20714; GeneCards: UBE2D1; OMA:UBE2D1 - orthologs
EC number	2.3.2.24
Gene location (Human)
Chr.	Chromosome 10 (human)
End	58,370,751 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	71,121,092 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; right ventricle; ; muscle of thigh; ; monocyte; ; gastrocnemius muscle; ; body of tongue; ; thoracic diaphragm;
	Top expressed in
	interventricular septum; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; quadriceps femoris muscle; ; muscle of thigh; ; tail of embryo; ; temporal muscle; ; genital tubercle; ; skeletal muscle tissue; ; ankle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ubiquitin conjugating enzyme activity; ATP binding; protein binding; ubiquitin-protein transferase activity; ubiquitin protein ligase binding;
Cellular component	cytoplasm; nucleoplasm; cytosol; ubiquitin ligase complex; protein-containing complex;
Biological process	protein K48-linked ubiquitination; BMP signaling pathway; protein polyubiquitination; negative regulation of transcription by RNA polymerase II; anaphase-promoting complex-dependent catabolic process; positive regulation of protein ubiquitination; ubiquitin-dependent protein catabolic process; protein ubiquitination; protein deubiquitination; positive regulation of protein polyubiquitination; protein targeting to peroxisome; regulation of mitotic cell cycle phase transition; MyD88-independent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7321
	216080
	ENSG00000072401
	ENSMUSG00000019927
	P51668
	P61080
	NM_003338; NM_001204880
	NM_145420
	NP_001191809; NP_003329
	NP_663395
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072401 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019927 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Robinson PA, Leek JP, Ardley HC, Thompson J, Rose SA, Markham AF (March 1999). "Assignment of UBE2D1 to human chromosome bands 10q11.2→q21 by in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 247–8. doi:10.1159/000015195. PMID 10072594. S2CID 3059748.
^ Jensen JP, Bates PW, Yang M, Vierstra RD, Weissman AM (January 1996). "Identification of a family of closely related human ubiquitin conjugating enzymes". J Biol Chem. 270 (51): 30408–14. doi:10.1074/jbc.270.51.30408. PMID 8530467.
^ "Entrez Gene: UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072401 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019927 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072594-5] Robinson PA, Leek JP, Ardley HC, Thompson J, Rose SA, Markham AF (March 1999). "Assignment of UBE2D1 to human chromosome bands 10q11.2→q21 by in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 247–8. doi:10.1159/000015195. PMID 10072594. S2CID 3059748.

[pmid8530467-6] Jensen JP, Bates PW, Yang M, Vierstra RD, Weissman AM (January 1996). "Identification of a family of closely related human ubiquitin conjugating enzymes". J Biol Chem. 270 (51): 30408–14. doi:10.1074/jbc.270.51.30408. PMID 8530467.

[entrez-7] "Entrez Gene: UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)".

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