regulation of double-strand break repair via homologous recombination
DNA metabolic process
positive regulation of DNA ligation
cellular response to camptothecin
double-strand break repair via homologous recombination
cellular response to ionizing radiation
mitotic recombination
protein homooligomerization
DNA repair
DNA unwinding involved in DNA replication
cellular response to DNA damage stimulus
interstrand cross-link repair
DNA recombinase assembly
negative regulation of G0 to G1 transition
telomere maintenance via recombination
telomere maintenance via telomere lengthening
replication fork processing
meiosis
chromosome organization involved in meiotic cell cycle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5888
19361
Ensembl
ENSG00000051180
n/a
UniProt
Q06609
Q08297
RefSeq (mRNA)
NM_001164269 NM_001164270 NM_002875 NM_133487
NM_011234
RefSeq (protein)
NP_001157741 NP_001157742 NP_002866 NP_597994
NP_035364
Location (UCSC)
Chr 15: 40.69 – 40.73 Mb
n/a
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA and yeast Rad51.[4][5] The protein is highly conserved in most eukaryotes, from yeast to humans.[6]
The name RAD51 derives from RADiation sensitive protein 51.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000051180 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shinohara A, Ogawa H, Ogawa T (May 1992). "Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein". Cell. 69 (3): 457–70. doi:10.1016/0092-8674(92)90447-K. PMID 1581961. S2CID 35937283.
^Seitz EM, Brockman JP, Sandler SJ, Clark AJ, Kowalczykowski SC (May 1998). "RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange". Genes & Development. 12 (9): 1248–53. doi:10.1101/gad.12.9.1248. PMC 316774. PMID 9573041.
^Shinohara A, Ogawa H, Matsuda Y, Ushio N, Ikeo K, Ogawa T (July 1993). "Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA". Nature Genetics. 4 (3): 239–43. doi:10.1038/ng0793-239. PMID 8358431. S2CID 28220010.
^Khoo, Kelvin H. P.; Jolly, Hayley R.; Able, Jason A. (2008). "The RAD51 gene family in bread wheat is highly conserved across eukaryotes, with RAD51A upregulated during early meiosis". Functional Plant Biology. 35 (12): 1267–1277. doi:10.1071/fp08203. ISSN 1445-4408. PMID 32688873.
DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the RAD51 protein family which...
the recombinase RAD51 to stimulate and maintain strand invasion, a vital step of homologous recombination. The localization of RAD51 to the DNA double-strand...
"S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51". Blood. 100 (7): 2414–20. doi:10.1182/blood-2002-01-0278. PMID 12239151...
recombinational repair. The RadA recombinase has greater similarity to the eukaryotic Rad51 recombinase than to the bacterial RecA recombinase. RecA recombinase appears...
Homologs of the recA gene, including rad51, play a key role in homologous recombinational repair of DNA during meiosis. A rad51 homolog is present in the anther...
binds the single strand DNA and directly interacts with the recombinase RAD51 to stimulate strand invasion, a vital step of homologous recombination,...
meiosis to produce pollen grains. Meiosis in maize requires gene product RAD51, a protein employed in recombinational repair of DNA double-strand breaks...
called DMC1, which is a conserved homologue of genes recA in bacteria and RAD51 in eukaryotes, that mediates homologous chromosome pairing during meiosis...
protein RAD51 homolog 4 is a protein that in humans is encoded by the RAD51L3 gene. The protein encoded by this gene is a member of the RAD51 protein...
recombinational DNA repair system. This repair system involves a homolog of Rad51 that has a very similar sequence and size to its mammalian counterparts...
such particular protein complex that is conserved between processes is RAD51, a well conserved recombinase protein that has been shown to be crucial...
identified in the Acanthamoeba genome. These genes included Spo11, Mre11, Rad50, Rad51, Rad52, Mnd1, Dmc1, Msh and Mlh. This finding suggests that the ‘'Acanthamoeba'’...
repair and mutagenesis are induced. The system involves the RecA protein (Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is...
RAD51 homolog C (S. cerevisiae), also known as RAD51C, is a protein which in humans is encoded by the RAD51C gene. The RAD51C protein is one of five paralogs...
necessary for homologous recombinational repair during meiosis (BRCA1, MRE11, Rad51, and ATM) decline with age in oocytes. This age-related decline in ability...
damages. The over-expression of RAD51 and BRCA2 seen in these cancers may reflect selective pressures for compensatory RAD51 or BRCA2 over-expression and...
Rad51, Dmc1 and RadA proteins indicate that they are monophyletic, or that they share a common molecular ancestor. Within this protein family, Rad51 and...
the recombinational DNA repair pathway. In particular, expression of the Rad51 protein (a recombinase) is increased about 15-fold by UV treatment. List...
PMID 1427035. Botthof JG, Bielczyk-Maczyńska E, Ferreira L, Cvejic A (May 2017). "rad51 leads to Fanconi anemia-like symptoms in zebrafish". Proceedings of the...
humans is encoded by the XRCC2 gene. This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to...
DNA recombination protein RAD51, which suggested its role in RAD51-related DNA recombination and repair. RAD52 mediates RAD51 function in homologous recombinational...
recombination reaction is catalyzed by enzymes known as recombinases, such as RAD51. The first step in recombination is a double-stranded break caused by either...
break (DSB) repair. Polyamines enhance the DNA strand exchange activity of RAD51 recombinase. Depletion of polyamines sensitizes cells to genotoxic substances...
"S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51". Blood. 100 (7): 2414–20. doi:10.1182/blood-2002-01-0278. PMID 12239151...
conserved homologue of genes recA in bacteria, and rad51 in eukaryotes (see articles recA and rad51). Dmc1 mediates homologous chromosome pairing during...
Global Information
