double-strand break repair via nonhomologous end joining
double-strand break repair
DNA repair
double-strand break repair via homologous recombination
chromatin organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3014
15270
Ensembl
ENSG00000188486
ENSMUSG00000049932
UniProt
P16104
P27661
RefSeq (mRNA)
NM_002105
NM_010436
RefSeq (protein)
NP_002096
NP_034566
Location (UCSC)
Chr 11: 119.09 – 119.1 Mb
Chr 9: 44.25 – 44.25 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. An important phosphorylated form is γH2AX (S139), which forms when double-strand breaks appear.
In humans and other eukaryotes, the DNA is wrapped around histone octamers, consisting of core histones H2A, H2B, H3 and H4, to form chromatin. H2AX contributes to nucleosome-formation, chromatin-remodeling and DNA repair, and is also used in vitro as an assay for double-strand breaks in dsDNA.
^ abcGRCh38: Ensembl release 89: ENSG00000188486 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000049932 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. An important phosphorylated form is γH2AX (S139), which forms when...
genes in the human genome, including: H2AFB1, H2AFB2, H2AFB3, H2AFJ, H2AFV, H2AFX, H2AFY, H2AFY2, and H2AFZ. Genetic patterns among the different H2A molecules...
cell cycle causes Bloom syndrome protein to rapidly form foci with gamma H2AFX protein at replication forks that develop DNA breaks. These BLM foci then...
mitosis. MDC1 has been shown to interact with: APC/C, ATM, CHEK2, γH2AX, H2AFX, MRE11A, NBS1, RAD51, RNF8, TOPOα, p53, and MDM2 MDC1 also binds to mRNA...
with: AURKB, BCL3, BRCA1, BRCA2, BRCC3, BRE, CSTF1, CSTF2, EWSR1, FANCD2, H2AFX, NPM1, P53, RAD51, TACC1, and UBE2D1. If a cancer cell's capacity to repair...