Phenylpiperazine compound
Triazoledione Other names BMS-180492 Elimination half-life 18 hours[1]
1-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-4-(2-phenoxyethyl)-1,2,4-triazolidine-3,5-dione
CAS Number PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) DTXSID701122505 Formula C 23 H 28 Cl N 5 O 3 Molar mass 457.96 g·mol−1 3D model (JSmol)
C1CN(CCN1CCCN2C(=O)N(C(=O)N2)CCOC3=CC=CC=C3)C4=CC(=CC=C4)Cl
InChI=1S/C23H28ClN5O3/c24-19-6-4-7-20(18-19)27-14-12-26(13-15-27)10-5-11-29-23(31)28(22(30)25-29)16-17-32-21-8-2-1-3-9-21/h1-4,6-9,18H,5,10-17H2,(H,25,30)
Key:BTNXVMLCKOPOEP-UHFFFAOYSA-N
Triazoledione (developmental code name BMS-180492 ) is a phenylpiperazine compound and a major metabolite of the antidepressant nefazodone.[2] [3] It is active, but with substantially reduced potency compared to nefazodone (approximately one-seventh).[3] [2] As such, it has been suggested that it is unlikely that triazoledione contributes significantly to the pharmacology of nefazodone.[3] However, triazoledione may reach concentrations as great as 10 times those of nefazodone, and hence could still be a significant contributor to its therapeutic effects.[2]
^ Golden RN, Dawkins K, Nicholas L (2017). "Trazodone and Nefazodone". In Schatzberg AF, Nemeroff CB (eds.). The American Psychiatric Association Publishing Textbook of Psychopharmacology (Fifth ed.). American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9 .
^ a b c Preskorn SH, Catterson ML (6 December 2012). "General Principles of Pharmacokinetics". In Preskorn SH, Stanga CY, Feighner JP, Ross R (eds.). Antidepressants: Past, Present and Future . Springer Science & Business Media. pp. 68–. ISBN 978-3-642-18500-7 .
^ a b c Davis R, Whittington R, Bryson HM (April 1997). "Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression". Drugs . 53 (4): 608–636. doi:10.2165/00003495-199753040-00006. PMID 9098663. S2CID 239077479.
Last Update: 2023-12-23T08:30:05Z
Triazoledione (developmental code name BMS-180492) is a phenylpiperazine compound and a major metabolite of the antidepressant nefazodone. It is active...
Word Count : 300
Last Update: 2024-03-11T21:44:39Z
half-lives of triazoledione and mCPP are longer at around 18 hours and 4 to 8 hours, respectively. Due to its long elimination half-life, triazoledione is the...
Word Count : 2970
Last Update: 2024-06-05T19:34:10Z
Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione , vilazodone, vortioxetine) Atypical antipsychotics (e.g., aripiprazole...
Word Count : 10073
Last Update: 2024-05-23T00:14:08Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline...
Word Count : 1350
Last Update: 2024-04-05T05:21:37Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline...
Word Count : 1711
Last Update: 2024-05-25T03:57:58Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 7108
Last Update: 2024-06-04T04:37:54Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline...
Word Count : 3137
Last Update: 2024-06-05T21:00:49Z
Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione , vilazodone, vortioxetine) Atypical antipsychotics (e.g., aripiprazole...
Word Count : 11998
Last Update: 2024-06-05T12:12:29Z
Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione , vilazodone, vortioxetine) Atypical antipsychotics (e.g., aripiprazole...
Word Count : 14641
Last Update: 2024-05-20T10:26:11Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 9149
Last Update: 2024-06-09T08:23:14Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 4746
Last Update: 2024-05-23T22:22:46Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 6615
Last Update: 2024-06-03T17:17:23Z
Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione , vilazodone, vortioxetine) Atypical antipsychotics (e.g., aripiprazole...
Word Count : 10327
Last Update: 2024-05-05T10:21:42Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline...
Word Count : 1209
Last Update: 2024-05-26T23:14:51Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 1690
Last Update: 2024-01-22T04:39:46Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline...
Word Count : 3073
Last Update: 2024-05-12T05:05:33Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 2905
Last Update: 2024-05-25T11:12:24Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 972
Last Update: 2024-05-25T11:10:50Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 2681
Last Update: 2024-06-06T14:38:34Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline...
Word Count : 3298
Last Update: 2024-06-05T21:19:19Z
Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione , vilazodone, vortioxetine) Atypical antipsychotics (e.g., aripiprazole...
Word Count : 13898
Last Update: 2024-05-24T17:48:58Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 8668
Last Update: 2024-05-25T02:04:04Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 3708
Last Update: 2024-05-25T19:38:42Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 10014
Last Update: 2024-06-02T08:45:20Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline...
Word Count : 6166
Last Update: 2024-06-02T11:35:20Z
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone...
Word Count : 7807