Tetanolysin information

Search for
Structures	Swiss-model
Domains	InterPro

Tetanolysin
Tetanolysin
Identifiers
Organism	Clostridium tetani
Symbol	tly
UniProt	Q893D9
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Tetanolysin is a toxin produced by Clostridium tetani bacteria. Its function is unknown, but it is believed to contribute to the pathogenesis of tetanus. The other C. tetani toxin, tetanospasmin, is more definitively linked to tetanus. It is sensitive to oxygen.

Tetanolysin belongs to a family of protein toxins known as thiol-activated cytolysins, which bind to cholesterol.^[1] It is related to streptolysin O and the θ-toxin of Clostridium perfringens.^[2] Cytolysins form pores in the cytoplasmic membrane that allows for the passage of ions and other molecules into the cell. The molecular weight of tetanolysin is around 55,000 daltons.^[3]

^ Billington, Stephen J.; Jost, B.Helen; Songer, J.Glenn (January 2000). "Thiol-activated cytolysins: structure, function and role in pathogenesis". FEMS Microbiology Letters. 182 (2): 195–205. doi:10.1111/j.1574-6968.2000.tb08895.x. PMID 10620666.
^ Roper MH, Wassilak SG, Tiwari TS, Orenstein WA (2013). "Tetanus toxoid". Vaccines (6th ed.). pp. 746–772. doi:10.1016/B978-1-4557-0090-5.00039-2. ISBN 9781455700905.
^ Tetanolysin

[1] Billington, Stephen J.; Jost, B.Helen; Songer, J.Glenn (January 2000). "Thiol-activated cytolysins: structure, function and role in pathogenesis". FEMS Microbiology Letters. 182 (2): 195–205. doi:10.1111/j.1574-6968.2000.tb08895.x. PMID 10620666.

[2] Roper MH, Wassilak SG, Tiwari TS, Orenstein WA (2013). "Tetanus toxoid". Vaccines (6th ed.). pp. 746–772. doi:10.1016/B978-1-4557-0090-5.00039-2. ISBN 9781455700905.

[3] Tetanolysin

Tetanolysin information

and 27 Related for: Tetanolysin information

Tetanolysin

Clostridium tetani

Tetanus toxin

Fish

Ricin

Botulinum toxin

Poison dart frog

Tetrodotoxin

Aflatoxin

Clostridium botulinum

Lipopolysaccharide

Aflatoxin B1

Neurotoxin

Cardiotoxicity

Muscimol

Amatoxin

Exotoxin

Hemotoxin

Shiga toxin

Clostridium perfringens

Ochratoxin

Lipid A

Toxin

Snake venom

Virulence factor

Mycotoxin

Delta endotoxins