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Chemical compound
Muscimol (also known as agarin or pantherine) is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABAA receptor[3] and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity. This colorless or white solid is classified as an isoxazole.
Muscimol went under clinical trial phase I for epilepsy, but the trial was discontinued.[4]
Muscimol, an agonist for the GABAA receptor, was able to significantly alleviate pain in its peak effect, recent studies from 2023 show. It has since been federally banned in Australia and is pending FDA review in the United States, but scientists believe it may relieve pain as well as some opioids without much of the risk of addiction associated with opioids. [5]
^The Merck Index, 12th Edition
^"Muscimol". pubchem.ncbi.nlm.nih.gov.
^Johnston GA (October 2014). "Muscimol as an ionotropic GABA receptor agonist". Neurochemical Research. 39 (10): 1942–1947. doi:10.1007/s11064-014-1245-y. PMID 24473816. S2CID 13364321.
^Heiss JD, Walbridge S, Rene'Smith RN, Sato S, Oldfield EH, Lonser RR (August 2012). "174 Convection-Enhanced Delivery of Muscimol to the Epileptic FocusPreclinical and Clinical Research". Neurosurgery. 71 (2): E568. doi:10.1227/01.neu.0000417764.02569.dc. ISSN 0148-396X.
^Ramawad HA, Paridari P, Jabermoradi S, Gharin P, Toloui A, Safari S, Yousefifard M (2023). "Muscimol as a treatment for nerve injury-related neuropathic pain: A systematic review and meta-analysis of preclinical studies". The Korean Journal of Pain. 36 (4): 425–440. doi:10.3344/kjp.23161. PMC 10551397. PMID 37732408.
Muscimol (also known as agarin or pantherine) is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol...
hallucinogenic properties, with the main psychoactive constituents being muscimol and its neurotoxic precursor ibotenic acid. A local variety of the mushroom...
temperate and boreal regions of the northern hemisphere. It is a prodrug of muscimol, broken down by the liver to that much more stable compound. It is a...
This is a list of the legality of muscimol mushrooms by country. "The Poisons Standard". Federal Register of Legislation. Archived from the original on...
by these peoples. Amanita pantherina contains the psychoactive compound muscimol, but is used as an entheogen much less often than its much more distinguishable...
poisonous. A. pantherina contains the psychoactive compounds ibotenic acid and muscimol, two psychoactive constituents which can cause effects such as hallucinations...
Clitocybe clavipes. Ibotenic acid: Decarboxylates into muscimol upon ingestion. The effects of muscimol vary, but nausea and vomiting are common. Confusion...
help nausea or stomach pain when added into a tea or peppermint candies. Muscimol is purported to have antiemetic activity. Ajwain is purported to be antiemetic...
people of South Africa to induce lucid dreams. Amanita muscaria (contains muscimol) Amphetamines and other stimulants can create psychotic episodes (called...
agaric) and Psilocybe cubensis, with the former containing alkaloids such as muscimol and the latter predominately psilocybin. Edible mushrooms include many...
dorsal horn neurons." Next, the GABA A agonist muscimol was tested in conjuncture with SP. Intrathecal muscimol significantly enhanced SP-induced hypersensitivity...
A. pantherina, among others, contain the psychoactive compound muscimol. The muscimol-containing chemotaxonomic group of Amanitas contains no amatoxins...
ibotenic acid (found in Amanita muscaria ("Fly Agaric"); prodrug to muscimol) muscimol (also found in Amanita muscaria, a GABAergic) Dissociatives dextromethorphan...
GABAA receptor is the binding site for GABA and several drugs such as muscimol, gaboxadol, and bicuculline. The protein also contains a number of different...
4-c)pyridin-3-ol (THIP), is a conformationally constrained derivative of the alkaloid muscimol that was first synthesized in 1977 by the Danish chemist Poul Krogsgaard-Larsen...
drugs include various psychoactive mushrooms containing psilocybin or muscimol and cacti containing mescaline and other chemicals, along with myriad other...
anticonvulsant action of classical 1,4-benzodiazepines (such as diazepam) and muscimol, but not sodium valproate, carbamazepine, phenobarbital, or phenytoin....
pallidus, induces an increased heart rate. Conversely, microinjections of muscimol, a GABA-a agonist, inhibit tachycardia in rats under air-stress stimuli...
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