TRAF6 is a TRAF human protein. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins...
signal transduction through tumor necrosis factor receptor members such as TRAF6, which results in the release of nuclear factor κB (NF-κB) transcription...
have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7. Except for TRAF7, these proteins share a relatively conserved...
its receptor complex. IRAK-1 dissociates from the receptor alongside of TRAF6 - a ubiquitin E3 ligase that intermediates between various types of receptors...
CARD (Caspase activation and recruitment domains) domains; that then binds TRAF6, which is ubiquitinated at K63.: 513–523 This form of ubiquitination does...
IKKgamma and TRAF6. The interact of Znf216 with IKK-gamma and RIP is mediated by the A20 zinc-finger domain, while its interaction with TRAF6 is mediated...
continuous. TRAF6 has been shown to be imperative to the RANK-related osteoclastogenesis pathway. RANKL binds to RANK, which then binds to TRAF6. TRAF6 stimulates...
is encoded by the MAST2 gene. The protein encoded by this gene controls TRAF6 and NF-kappaB activity. MAST2 has been shown to interact with PCLKC. GRCh38:...
demonstrated that ligand-occupied TGF-β receptors can directly trigger the TRAF6-TAK1 signalling module, resulting in MAP kinase activation. Here we report...
This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate...
family proteins, in particular, TRAF6 in order to activate the NF-κB pathway. Indeed, Act1 polyubiquitinates TRAF6. TRAF6 will then be activated and recruit...
adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Molecular Cell. 5 (4): 649–58...
2015-01-05. Noels H, van Loo G, Hagens S, et al. (April 2007). "A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation...
when compared to other cytokine receptors. Transcription factors such as TRAF6, JNK, Erk1/2, p38, AP-1 and NF-κB have been implicated in IL-17 mediated...
shown to interact with TNIP1, TRAF1, TRAF2, IKBKG, TAX1BP1, YWHAB, YWHAZ, TRAF6 and YWHAH. The TNFAIP3 locus is implicated as a positively associated factor...
and IRAK2 to form a signaling complex. The signaling complex reacts with TRAF6 which leads to TAK1 activation and consequently the induction of inflammatory...
involving SRC kinase and tumor necrosis factor receptor-associated factor 6 (TRAF6), indicating that RANKL may have a role in the regulation of apoptosis....
complex. This signaling complex in turn triggers downstream recruitment of TRAF6 and NF-κB activation. A wide range of ligands promote signalling through...
suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, which otherwise stimulates the production...
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