Interleukin-1 receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the IRAK1 gene.[5][6] IRAK-1 plays an important role in the regulation of the expression of inflammatory genes by immune cells, such as monocytes and macrophages, which in turn help the immune system in eliminating bacteria, viruses, and other pathogens. IRAK-1 is part of the IRAK family consisting of IRAK-1, IRAK-2, IRAK-3, and IRAK-4, and is activated by inflammatory molecules released by signaling pathways during pathogenic attack.[7] IRAK-1 is classified as a kinase enzyme, which regulates pathways in both innate and adaptive immune systems.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000184216 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031392 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^Jain A, Kaczanowska S, Davila E (2014). "IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance". Frontiers in Immunology. 5: 553. doi:10.3389/fimmu.2014.00553. PMC 4233944. PMID 25452754.
^Deng Y, Hahn BH, Tsao BP (2013). "Systemic Lupus Erythematosus". Emery and Rimoin's Principles and Practice of Medical Genetics: 1–22. doi:10.1016/B978-0-12-383834-6.00081-1. ISBN 9780123838346.
receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the IRAK1 gene. IRAK-1 plays an important role in the regulation of the expression...
domain structures which are similar to those of IRAK1, IRAK2, IRAKM and Pelle. IRAK4 is unique compared to IRAK1, IRAK2 and IRAKM in that it functions upstream...
receptor. Mutations involving the production of extra copies of the MECP2 and IRAK1 genes within Xq28 have been associated with phenotypes including anxiety...
MiRNA-146a/b-5p indirectly represses IL-8 expression by silencing the expression of IRAK1. Additionally, the 3'UTR of IL-8 contains a A/U-rich element that makes...
and TRAM. These adapters activate other intracellular molecules such as IRAK1, IRAK4, TBK1, and IKKi that amplify the signal, eventually leading to the...
Waldenström's macroglobulinemia. Myd88 has been shown to interact with: IRAK1 IRAK2 Interleukin 1 receptor, type I RAC1 TLR 4 Various single nucleotide...
and dendritic cells. MyD88 attracts the IRAK4 molecule, IRAK4 recruits IRAK1 and IRAK2 to form a signaling complex. The signaling complex reacts with...
Pellino function is speculation; however, Pellino proteins can associate with IRAK1, TRAF6, and TAK1 following IL-1R activation, indicating that they may assemble...
"Neolithic Heartbeat" – 4:22 "Tempus Fugit" – 3:03 "Jesus Gone" – 10:49 "Irak1 (A Tribute to Ernst Horn)" – 4:10 Official homepage Fan page with detailed...
has been shown to interact with HDAC9, CDC37, CHUK CTNNB1, FANCA, IKBKG IRAK1, NFKBIA, MAP3K14, NFKB1, NFKBIB, NCOA3, PPM1B, TNFRSF1A, and TRAF2. GRCh38:...
protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling...
a 2023 song by Lil Durk named after the brand An enzyme, also known as IRAK1 A familiar form of the male given name Per Another name of Pella (Thessaly)...
RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2". Journal of Immunology. 183 (3): 2150–2158. doi:10.4049/jimmunol...
Kollewe C, Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5...
differentially regulates neuroimmune-related Interleukin-1R associated kinases IRAK1 and IRAK2 expression, in human AD brain, while other studies have shown...
have been described. It has been suggested that MAPK3, along with the gene IRAK1, is turned off by two microRNAs that were activated after the influenza...
injection. IKBKG has been shown to interact with: BCL10, CDC37, CHUK and IKK2, IRAK1, NCOA3, PPM1B, TANK, TNFAIP3, TRAF3IP2, and TRAF6. GRCh38: Ensembl release...
contributes to the regulation of cell growth; 2) missense mutations in the IRAK1 gene which causes overactivation of its product protein, interleukin-1 receptor-associated...
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