MAST2 information

MAST2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KQF, 2KYL
Identifiers
Aliases	MAST2, MAST205, MTSSK, microtubule associated serine/threonine kinase 2
External IDs	OMIM: 612257; MGI: 894676; HomoloGene: 7428; GeneCards: MAST2; OMA:MAST2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	46,036,122 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	116,464,183 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; gastric mucosa; ; stromal cell of endometrium; ; pancreatic ductal cell; ; skeletal muscle tissue; ; left ventricle; ; quadriceps femoris muscle; ; transverse colon; ; vastus lateralis muscle; ; parotid gland;
	Top expressed in
	internal carotid artery; ; right ventricle; ; ankle joint; ; external carotid artery; ; ankle; ; digastric muscle; ; soleus muscle; ; temporal muscle; ; triceps brachii muscle; ; gastrocnemius muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; phosphatase binding; microtubule binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding;
Cellular component	membrane; microtubule cytoskeleton; plasma membrane; cytoskeleton; cytoplasm;
Biological process	intracellular signal transduction; phosphorylation; spermatid differentiation; protein phosphorylation; cytoskeleton organization; peptidyl-serine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23139
	17776
	ENSG00000086015
	ENSMUSG00000003810
	Q6P0Q8
	Q60592
	NM_015112; NM_001319245; NM_001324320; NM_001324321
	NM_001042743; NM_008641; NM_001369061; NM_001369062
	NP_001306174; NP_001311249; NP_001311250; NP_055927
	NP_001036208; NP_032667; NP_001355990; NP_001355991
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene.^[5] The protein encoded by this gene controls TRAF6 and NF-kappaB activity.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000086015 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003810 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2".
^ Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability". J. Biol. Chem. 279 (42): 43675–83. doi:10.1074/jbc.M404328200. PMID 15308666.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086015 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003810 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_23139-5] "Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2".

[pmid_15308666-6] Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability". J. Biol. Chem. 279 (42): 43675–83. doi:10.1074/jbc.M404328200. PMID 15308666.

MAST2 information

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PDZ domain