TNF receptor associated factors (TRAFs) are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.[1]
Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7.
Except for TRAF7, these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40.
^Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T (January 2000). "Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling". Exp. Cell Res. 254 (1): 14–24. doi:10.1006/excr.1999.4733. PMID 10623461.
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