In biology, scaffold proteins are crucial regulators of many key signalling pathways. Although scaffolds are not strictly defined in function, they are known to interact and/or bind with multiple members of a signalling pathway, tethering them into complexes. In such pathways, they regulate signal transduction and help localize pathway components (organized in complexes) to specific areas of the cell such as the plasma membrane, the cytoplasm, the nucleus, the Golgi, endosomes, and the mitochondria.
In biology, scaffoldproteins are crucial regulators of many key signalling pathways. Although scaffolds are not strictly defined in function, they are...
the chromosome scaffold is the backbone that supports the structure of the chromosomes. It is composed of a group of non-histone proteins that are essential...
carboxysomes do not form. The α-carboxysomal scaffoldprotein is called CsoS2, and the β-carboxysomal scaffoldprotein is called CcmM. Though CsoS2 and CcmM...
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved...
interact with one another in one or more larger protein complexes. If one of the components is missing, this protein complex cannot fulfil its function in the...
discussed with regards to adaptor proteins: Pawson, T. (1997). "Signaling Through Scaffold, Anchoring, and Adaptor Proteins". Science. 278 (5346): 2075–2080...
increases Notch on the surface of the cell that continues as a stem cell. Scaffoldprotein Biosemiotics Molecular cellular cognition Crosstalk (biology) Bacterial...
membrane fractions. It has a role as a scaffoldprotein which cross-links and anchors Tight Junction (TJ) strand proteins, which are fibril-like structures...
conserved. Hpo can bind to and phosphorylate Sav, which may function as a scaffoldprotein because this Hpo-Sav interaction promotes phosphorylation of Wts. Hpo...
protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein...
known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffoldprotein which in humans is encoded by the SCRIB gene. It was originally isolated...
Microtubule associated scaffoldprotein 2 is a protein that in humans is encoded by the MTUS2 gene. GRCh38: Ensembl release 89: ENSG00000132938 – Ensembl...
the protein and further damage to the nervous system. The aggregation of phosphorylated α-Synuclein can be enhanced if a presynaptic scaffoldprotein, Sept4...
subunits: the DEAD-box RNA helicase eIF4A, the cap-binding protein eIF4E, and the large "scaffold" protein eIF4G. The mammalian eIF4F complex was first described...
synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues...
of an oxygen-sensitive potassium channel coupled to an oxygen sensory protein in the rabbit lumenal membrane. They are hypothetically involved in regulating...
inhibits Bad (a Bcl-2 family member), causing Bad to interact with the 14-3-3 scaffold, resulting in Bcl dissociation and thus cell survival. Akt also activates...
parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the...
mitochondrial is a protein that in humans is encoded by the ISCU gene. It encodes an iron-sulfur (Fe-S) cluster scaffoldprotein involved in [2Fe-2S]...
Fus3 protein (a MAPK protein) and the phosphatase Ptc1. These proteins both attempt to control the 4 phosphorylation sites of Ste5, a scaffoldprotein with...
separate scaffolding proteins, the delta domain of HK97 MCP, which faces toward the inside of the capsid, acts as a scaffoldprotein. A cylindrical opening...
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