Ocaperidone
Names
Preferred IUPAC name
3-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2,9-dimethyl-4H -pyrido[1,2-a ]pyrimidin-4-one
Identifiers
CAS Number
129029-23-8 Y
3D model (JSmol)
ChemSpider
IUPHAR/BPS
KEGG
MeSH
C072259
UNII
26HUS7139V Y
DTXSID10156042
InChI=1S/C24H25FN4O2/c1-15-4-3-10-29-23(15)26-16(2)19(24(29)30)9-13-28-11-7-17(8-12-28)22-20-6-5-18(25)14-21(20)31-27-22/h3-6,10,14,17H,7-9,11-13H2,1-2H3
Key: ZZQNEJILGNNOEP-UHFFFAOYSA-N
InChI=1/C24H25FN4O2/c1-15-4-3-10-29-23(15)26-16(2)19(24(29)30)9-13-28-11-7-17(8-12-28)22-20-6-5-18(25)14-21(20)31-27-22/h3-6,10,14,17H,7-9,11-13H2,1-2H3
Key: ZZQNEJILGNNOEP-UHFFFAOYAT
CC1=CC=CN2C1=NC(=C(C2=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F)C
Properties
Chemical formula
C 24 H 25 F N 4 O 2
Molar mass
420.488 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Ocaperidone (R 79598 ) is a benzisoxazole antipsychotic.[1] It was initially developed by Janssen, later licensed to French laboratory Neuro3D and then acquired in 2007 by German company Evotec. It was found to be more potent than risperidone in animal studies,[2] but its testing was abandoned in 2010 after unfavorable results in human Phase II trials,[3] as while it was effective at controlling symptoms of schizophrenia, ocaperidone produced an unacceptable amount of extrapyramidal side effects.[4]
^ Leysen, JE; Janssen, PM; Gommeren, W; Wynants, J; Pauwels, PJ; Janssen, PA (1992). "In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone". Molecular Pharmacology . 41 (3): 494–508. PMID 1372084.
^ Megens AA, Awouters FH, Meert TF, Schellekens KH, Niemegeers CJ, Janssen PA. Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther . 1992 Jan;260(1):146-59. PMID 1370538
^ "Ocaperidone — AdisInsight". Adis Insight . Adis International Ltd, part of Springer Science+Business Media. Retrieved 10 December 2015 .
^ Geerts H, Spiros A, Roberts P, Twyman R, Alphs L, Grace AA. Blinded prospective evaluation of computer-based mechanistic schizophrenia disease model for predicting drug response. PLoS One . 2012;7(12):e49732. doi:10.1371/journal.pone.0049732 PMID 23251349
Last Update: 2023-02-06T15:53:53Z
Ocaperidone (R 79598) is a benzisoxazole antipsychotic. It was initially developed by Janssen, later licensed to French laboratory Neuro3D and then acquired...
Word Count : 278
Last Update: 2024-05-26T23:14:51Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 1690
Last Update: 2024-05-25T11:10:50Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 2681
Last Update: 2024-06-03T17:01:24Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 14161
Last Update: 2024-04-02T05:19:08Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 6534
Last Update: 2024-06-05T12:12:29Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 14641
Last Update: 2024-06-09T08:23:14Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 4746
Last Update: 2024-06-10T08:57:34Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 8406
Last Update: 2024-06-11T06:17:52Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 13889
Last Update: 2024-05-25T02:04:04Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 3708
Last Update: 2024-06-10T11:39:52Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 15793
Last Update: 2024-06-06T12:54:17Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 4916
Last Update: 2024-06-04T00:52:47Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 3754
Last Update: 2024-03-27T14:47:27Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 3892
Last Update: 2024-03-28T19:23:24Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 8663
Last Update: 2024-05-31T23:00:42Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 18194
Last Update: 2024-06-10T10:12:16Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 11401
Last Update: 2024-06-03T17:17:23Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 10327
Last Update: 2024-05-29T19:34:52Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 12545
Last Update: 2024-06-09T04:55:43Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 5375
Last Update: 2024-06-09T14:24:06Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 4561
Last Update: 2024-05-03T19:42:22Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 2293
Last Update: 2024-06-11T06:12:16Z
fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone , olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine...
Word Count : 1739
Last Update: 2024-05-25T02:00:20Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 5296
Last Update: 2024-05-23T04:29:15Z
Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine...
Word Count : 15614
Last Update: 2022-05-02T01:24:54Z
drugs such as some antipsychotics (including risperidone, paliperidone, ocaperidone , and iloperidone) and the anticonvulsant zonisamide. Its aromaticity...
Word Count : 342