Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches.[1] It is taken orally, intranasally, or by subcutaneous injection.[2] Therapeutic effects generally occur within three hours.[2]
Its primary effect as a serotonin 5-HT1B/5-HT1D receptor agonist[3] can create common side effects such as chest pressure, fatigue, vomiting, tingling, and vertigo.[2] Serious side effects may include serotonin syndrome, heart attacks, strokes, and seizures.[2] With excessive use, medication overuse headaches may occur.[2] It is unclear if use during pregnancy or breastfeeding is safe.[4] The mechanism of action is not entirely clear.[2] It is in the triptan class of medications.[2]
Sumatriptan was patented in 1982 and approved for medical use in 1991.[5] It is on the World Health Organization's List of Essential Medicines.[6] It is available as a generic medication.[1] In 2021, it was the 109th most commonly prescribed medication in the United States, with more than 5million prescriptions.[7][8] It is also available as the combination product sumatriptan/naproxen.
^ abBritish National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 474. ISBN 9780857113382.
^ abcdefg"Sumatriptan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^Syed YY (January 2016). "Sumatriptan/Naproxen Sodium: A Review in Migraine". Drugs. 76 (1): 111–121. doi:10.1007/s40265-015-0521-8. PMID 26628293. S2CID 25060147.
^"Sumatriptan Use During Pregnancy". Drugs.com. Retrieved 3 March 2019.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 531. ISBN 9783527607495.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Sumatriptan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches. It is taken orally...
nerve endings in the brain. The first clinically available triptan was sumatriptan, which has been marketed since 1991. Triptans have largely replaced ergotamines...
2010 review found rizatriptan to be more efficacious and tolerable than sumatriptan. Rizatriptan and other triptans can cause vasoconstriction, they are...
at marketed doses and that naratriptan, although less effective than sumatriptan and rizatriptan was more effective than placebo in reducing migraine...
nausea and vomiting. A third Migraleve variant, Migraleve Ultra, contains sumatriptan. The pink tablet is supposed to be taken before the yellow tablet. The...
associated with it including sulphonamides, such as sulfasalazine or sumatriptan. Another possible cause is occupational exposure to sulfur compounds...
beneficial effects on negative symptoms in schizophrenia. Triptans such as sumatriptan, rizatriptan, and naratriptan are 5-HT1B receptor agonists that are used...
Probenecid (uricosuric) Sulfasalazine (anti-inflammatory agent and a DMARD) Sumatriptan (antimigraine triptan) Brayfield, A, ed. (2 February 2011). "Sulfonamides...
relieve moderate to severe migraine pain, with an effectiveness similar to sumatriptan. Paracetamol, either alone or in combination with metoclopramide (an...
the first triptan drug, sumatriptan, that had both vasoconstriction effect, as well as better oral bioavailability. Sumatriptan was first launched in the...
phase, characterized by the anticipation of an episode, consists of sumatriptan (nasal or oral) an anti-migraine medication, anti-inflammatory drugs...
subcutaneous or intranasal sumatriptan. Sumatriptan and zolmitriptan have both been shown to improve symptoms during an attack with sumatriptan being superior. Because...
synthetic tryptamines have also been made, including the migraine drug sumatriptan, and psychedelic drugs. A 2022 study has found the variety of tryptamines...
of sumatriptan and metergoline at the human 5-HT1D beta receptor: further evidence for a role of the 5-HT1D receptor in the action of sumatriptan". European...
"Migraine-like symptoms triggered by occipital lobe seizures: response to sumatriptan". The Canadian Journal of Neurological Sciences. 25 (2): 151–3. doi:10...
as a nasal spray or injection and has an efficacy similar to that of sumatriptan. Nausea is a common side effect. It has similar actions to the triptans...
voriconazole) delavirdine, efavirenz, or a 5-HT1 receptor agonist (e.g., sumatriptan). Side effects of ergotamine include nausea and vomiting. At higher doses...
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