Multienzyme complex contains several copies of one or several enzymes (polypeptide chains) packed into one assembly. Multienzyme complex carries out a single or a series of biochemical reactions taking place in the cells. It allows to segregate certain biochemical pathways into one place in the cell.[1]
A multienzyme complex that functions in the histidine biosynthesis pathway has been studied at the biochemical and genetic level in the fungus Neurospora crassa. A gene (His-3) was found to encode a protein that functions as a multienzyme complex having three distinct enzymatic activities in the biosynthesis pathway.[2] A genetic analysis of mutants defective in the N. crassa histidine pathway indicated that the individual activities of the multienzyme complex occur in discrete regions of the His-3 genetic map. This finding suggested that each of the activities of the multienzyme complex are encoded separately from each other, but within the same gene.[2] Some His-3 mutants were also found that lacked all three activities simultaneously, suggesting that some mutations can cause loss of function of the whole multienzyme complex.
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Neuman, Nicole (2016). "The Complex Macromolecular Complex: Trends in Biochemical Sciences". Trends in Biochemical Sciences. 41 (1): 1–3. doi:10.1016/j.tibs.2015.11.006. PMID 26699226.
^ abAhmed A. Organization of the histidine-3 region of Neurospora. Mol Gen Genet. 1968;103(2):185-93. doi: 10.1007/BF00427145. PMID: 4306011
and 25 Related for: Multienzyme complex information
Multienzymecomplex contains several copies of one or several enzymes (polypeptide chains) packed into one assembly. Multienzymecomplex carries out a...
"Structure and symmetry of B. stearothermophilus pyruvate dehydrogenase multienzymecomplex and implications for eucaryote evolution". Cell. 17 (1): 85–93. doi:10...
UvrABC endonuclease is a multienzymecomplex in bacteria involved in DNA repair by nucleotide excision repair, and it is, therefore, sometimes called...
studied in the fungus Neurospora crassa, and a gene (His-3) encoding a multienzymecomplex was found that was similar to the His4 gene of the bacterium E. coli...
thioester product, is carried out by a complex and fascinating multienzymecomplex known as the pyruvate dehydrogenase complex (also sometimes abbreviated as...
pyruvate dehydrogenase complex (PDC), this enzyme forms a complex composed of three components: Three classes of these multienzymecomplexes have been characterized:...
(June 1976). "The tentative identification in Escherichia coli of a multienzymecomplex with glycolytic activity". Eur. J. Biochem. 66 (1): 25–36. doi:10...
Y, et al. (April 2002). "Structure of the pyruvate dehydrogenase multienzymecomplex E1 component from Escherichia coli at 1.85 A resolution". Biochemistry...
synthesis is complex, beginning with a 5-phosphoribosyl-1-pyrophosphate (PRPP). Enzymes taking part in IMP synthesis constitute a multienzymecomplex in the...
oxidizing pathways which are likely found in DHABs: sulfur-oxidizing multienzymecomplex which can oxidize sulfide or thiosulfate to sulfate (with elemental...
aerobic metabolism because RLA is an essential cofactor of many enzyme complexes. Lipoic acid contains two sulfur atoms connected by a disulfide bond in...
hgcAB genes. It is not known if the HgcA and HgcB proteins create a multienzymecomplex or work sequentially. It has also been shown that deletion of either...
of the enzymes for the fatty acid synthesis are organized into a multienzymecomplex called fatty acid synthase. The major sites of fatty acid synthesis...
release of the thioesterase component of the fatty acid synthetase multienzymecomplex by limited trypsinization". Proceedings of the National Academy of...
degradosome: structure, function and relationship in other ribonucleolytic multienzymecomplexes". Biochem. Soc. Trans. 30 (2): 150–5. doi:10.1042/BST0300150. PMID 12035760...
"Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzymecomplex from Salmonella typhimurium". The Journal of Biological Chemistry...
(PDK). Pyruvate dehydrogenase (PDH) is a part of a mitochondrial multienzymecomplex that catalyzes the oxidative decarboxylation of pyruvate and is one...
dehydrogenase kinase.The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzymecomplex that catalyzes the overall conversion of pyruvate...
their physical protein-protein interaction. Thus far, isolation of a multienzymecomplex inclusive of all purine biosynthesis enzymes has not been achieved...
Sheldon M. (1974). The Regulation of the Pyruvate Dehydrogenase MultienzymeComplex by Calcium and Magnesium in Heart Mitochondrial Systems (Ph.D. thesis)...
compound naringin that gives citrus juices its bitter taste. It is a multienzymecomplex which possesses alpha-L-rhamnosidase and beta glucosidase active...
biomolecules are non-covalent. Examples: Protein complexes, some of which are multienzymecomplexes: proteasome, DNA polymerase III holoenzyme, RNA polymerase...
PQQ-containing methanol dehydrogenase: a bacterial dehydrogenase in a multienzymecomplex". FEBS Letters. 168 (2): 217–221. doi:10.1016/0014-5793(84)80249-5...
a multienzymecomplex associated with the inner membrane of mitochondria, and functions in the catabolism of branched-chain amino acids. The complex consists...
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