Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation.[1] Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the glycolysis metabolic pathway to the citric acid cycle. Pyruvate decarboxylation is also known as the "pyruvate dehydrogenase reaction" because it also involves the oxidation of pyruvate.[2]
This multi-enzyme complex is related structurally and functionally to the oxoglutarate dehydrogenase and branched-chain oxo-acid dehydrogenase multi-enzyme complexes.
Pyruvatedehydrogenasecomplex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation...
pyrophosphate. Pyruvatedehydrogenase is usually encountered as a component, referred to as E1, of the pyruvatedehydrogenasecomplex (PDC). PDC consists...
Pyruvatedehydrogenase deficiency (also known as pyruvatedehydrogenasecomplex deficiency or PDCD or PDH deficiency) is a rare neurodegenerative disorder...
conversion of pyruvate into acetyl-CoA by the enzyme complexpyruvatedehydrogenasecomplex. The reaction may be simplified as: Pyruvate + NAD+ + CoA →...
carboxylic acid, malic acid, isocitric acid, etc. Pyruvate catalytic reaction catalyzed by pyruvatedehydrogenase system is a special decarboxylation method...
Pyruvatedehydrogenase kinase (also pyruvatedehydrogenasecomplex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme which acts to inactivate...
like pyruvatedehydrogenasecomplex (PDC), this enzyme forms a complex composed of three components: Three classes of these multienzyme complexes have...
component of the multienzyme pyruvatedehydrogenasecomplex. The pyruvatedehydrogenasecomplex is responsible for the pyruvate decarboxylation step that...
for an isozyme of pyruvatedehydrogenase kinase (PDK). Pyruvatedehydrogenase (PDH) is a part of a mitochondrial multienzyme complex that catalyzes the...
"GlycolysisGluconeogenesis_WP534". Pyruvate decarboxylation by the pyruvatedehydrogenasecomplex produces acetyl-CoA. Carboxylation by pyruvate carboxylase produces...
reverse the effects of pyruvatedehydrogenase kinase upon pyruvatedehydrogenase, activating pyruvatedehydrogenase. Pyruvatedehydrogenase (E1) is one of the...
"How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvatedehydrogenasecomplex". The Journal of Biological...
Pyruvatedehydrogenase lipoamide kinase isozyme 4, mitochondrial (PDK4) is an enzyme that in humans is encoded by the PDK4 gene. It codes for an isozyme...
components of the succinate dehydrogenasecomplex, α-ketoglutarate dehydrogenase, and a component of the pyruvatedehydrogenasecomplex. FAD can exist in four...
enzymes in humans: The most-studied of these is the pyruvatedehydrogenasecomplex. These complexes have three central subunits: E1-3, which are the decarboxylase...
which later degrades into pyruvate.: 88–90 Pyruvate is oxidized to acetyl-CoA and CO2 by the pyruvatedehydrogenasecomplex (PDC). The PDC contains multiple...
Pyruvatedehydrogenase kinase isoform 2 (PDK2) also known as pyruvatedehydrogenase lipoamide kinase isozyme 2, mitochondrial is an enzyme that in humans...
storm can compromise metabolic flexibility by inactivating the pyruvatedehydrogenasecomplex and other enzymes. Insulin resistance Goodpaster BH, Sparks...
isozyme of pyruvatedehydrogenase kinase.The pyruvatedehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes...
production. This protein may tightly associate or interact with the pyruvatedehydrogenasecomplex. Somatic mosaic mutations of this gene have also been found...
have antimitochondrial antibodies (AMAs) against pyruvatedehydrogenasecomplex (PDC-E2), an enzyme complex found in the mitochondria. People who are negative...
of sugars by glycolysis which yield pyruvate that in turn is decarboxylated by the pyruvatedehydrogenasecomplex generating acetyl-CoA according to the...
when pairs of hydrogen combine with pyruvate to form lactate. Lactate formation is catalyzed by lactate dehydrogenase in a reversible reaction. Lactate...
Global Information