"Ribbon view" of the human exosome complex. PDB 2NN6 See the legend below. The channel through which RNA passes during degradation is visible at the center of the protein complex
The exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of degrading various types of RNA (ribonucleic acid) molecules. Exosome complexes are found in both eukaryotic cells and archaea, while in bacteria a simpler complex called the degradosome carries out similar functions.
The core of the exosome contains a six-membered ring structure to which other proteins are attached. In eukaryotic cells, the exosome complex is present in the cytoplasm, nucleus, and especially the nucleolus, although different proteins interact with the exosome complex in these compartments regulating the RNA degradation activity of the complex to substrates specific to these cell compartments. Substrates of the exosome include messenger RNA, ribosomal RNA, and many species of small RNAs. The exosome has an exoribonucleolytic function, meaning it degrades RNA starting at one end (the 3′ end in this case), and in eukaryotes also an endoribonucleolytic function, meaning it cleaves RNA at sites within the molecule.
Several proteins in the exosome are the target of autoantibodies in patients with specific autoimmune diseases (especially the PM/Scl overlap syndrome) and some antimetabolic chemotherapies for cancer function by blocking the activity of the exosome. In addition, mutations in exosome component 3 cause pontocerebellar hypoplasia and spinal motor neuron disease.
The exosomecomplex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of degrading various types of...
Exosome may refer to: Exosomecomplex, an intracellular macromolecular protein complex involved in RNA degradation Exosome (vesicle), an extracellular...
, Vanacova et al. and Wyers et al. in 2005. It interacts with the exosomecomplex in the nucleus of eukaryotic cells and is involved in the 3' end processing...
2022 Complex Networks, publisher of the now-only-online magazine Complex Protein–ligand complex, a complex of a protein bound with a ligand Exosome complex...
exos means powered exoskeletons In medicine, exos is short for the exosomecomplex Lotus Exos, see Lotus Cars "EXOS", a 2016 song by Blank Banshee from...
Exosomecomplex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to...
arm and the Ski2 insertion domain. In yeast, the complex guides RNA molecules to the exosomecomplex for degradation via a fourth protein, called Ski7...
Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosomecomplex. Mutations in EXOSC3 cause pontocerebellar hypoplasia...
the main routes of RNA degradation is performed by the multi-protein exosomecomplex, which consists largely of 3′ to 5′ exoribonucleases. RNA polymerase...
destabilize the cap binding complex. The message is then subject to degradation by either the exosomecomplex or the decapping complex. In this way, translationally...
Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which (sometimes called RRP45 or PM/Scl-75) is part of the exosome...
Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosomecomplex. Exosome component 8 has been shown...
Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosomecomplex. Exosome component 4 has been shown to interact with...
EXOSC1 gene. This gene encodes a core component of the exosomecomplex. The mammalian exosome is required for rapid degradation of AU rich element-containing...
enzyme homologous to the yeast protein Rrp44, and can be part of the exosomecomplex in the cytoplasm of eukaryotic cells. GRCh38: Ensembl release 89: ENSG00000166938...
also strongly supported by two CSIs found in the proteins predicted exosomecomplex RRP44 and serine palmitoyltransferase, that are exclusively shared...
Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which (sometimes called PM/Scl-100) is part of the exosome complex...
and archaea, a structurally and evolutionary related complex exists, called the exosomecomplex. The same abbreviation (PNPase) is also used for another...
Exosomecomplex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene. This gene product constitutes one of the subunits of the multisubunit...
Exosome component 5, also known as EXOSC5, is a human gene, which is part of the exosomecomplex. Biallelic pathogenic variation in EXOSC5 causes autosomal...
supported by two CSIs found in the proteins Rrp44 (associated with exosomecomplex) and serine palmitoyltransferase, that are exclusively shared by species...
(1998). "Autoantibodies against a 210 kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis". J....
(such as RNase D or RNase PH) but also can be complexes of multiple proteins, such as the exosomecomplex (in which four of the major exoribonuclease families...
antibodies are components of the RNA-processing exosomecomplex in the nucleolus. There are ten proteins in this complex and antibodies to eight of them are found...
Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosomecomplex. Exosome component 7 has been shown...
biomarkers. Biology portal The Proteolysis Map DSS1/SEM1 protein family Exosomecomplex Endoplasmic-reticulum-associated protein degradation JUNQ and IPOD...
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