In biochemistry, a metabolon is a temporary structural-functional complex formed between sequential enzymes of a metabolic pathway, held together both by non-covalent interactions and by structural elements of the cell, such as integral membrane proteins and proteins of the cytoskeleton.
The formation of metabolons allows the intermediate product from one enzyme to be passed (channelling) directly into the active site of the next consecutive enzyme of the metabolic pathway. The citric acid cycle is an example of a metabolon that facilitates substrate channeling.[1][2] Another example is the dhurrin synthesis pathway in sorghum, in which the enzymes assemble as a metabolon in lipid membranes.[3] During the functioning of metabolons, the amount of water needed to hydrate the enzymes is reduced and enzyme activity is increased[citation needed].
^Wu, Fei; Minteer, Shelley (2 February 2015). "Krebs Cycle Metabolon: Structural Evidence of Substrate Channeling Revealed by Cross-Linking and Mass Spectrometry". Angewandte Chemie International Edition. 54 (6): 1851–1854. doi:10.1002/anie.201409336. PMID 25537779.
^Zhang, Youjun; Beard, Katherine F. M.; Swart, Corné; Bergmann, Susan; Krahnert, Ina; Nikoloski, Zoran; Graf, Alexander; Ratcliffe, R. George; Sweetlove, Lee J.; Fernie, Alisdair R.; Obata, Toshihiro (16 May 2017). "Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle". Nature Communications. 8: 15212. doi:10.1038/ncomms15212. PMC 5440813. PMID 28508886.
^Laursen, Tomas; Borch, Jonas; Knudsen, Camilla; Bavishi, Krutika; Torta, Federico; Martens, Helle Juel; Silvestro, Daniele; Hatzakis, Nikos S.; Wenk, Markus R. (2016-11-18). "Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum" (PDF). Science. 354 (6314): 890–893. doi:10.1126/science.aag2347. ISSN 0036-8075. PMID 27856908. S2CID 19187608.
In biochemistry, a metabolon is a temporary structural-functional complex formed between sequential enzymes of a metabolic pathway, held together both...
Steuernagel, Burkhard (2023-02-16). "Genomics and biochemical analyses reveal a metabolon key to β-L-ODAP biosynthesis in Lathyrus sativus". Nature Communications...
metabolic pathway channel substrates between themselves, this is called a metabolon. Channeling can make a metabolic pathway more rapid and efficient than...
Center International Society for Transgenic Technologies North Carolina Metabolon, Inc South Carolina Clemson Center for Human Genetics Greenwood Genetic...
transporter, and carbonic anhydrase into a macromolecular complex termed a "metabolon," which may play a key role in regulating red cell metabolism and ion...
metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes". Metabolon. Retrieved 3 November 2022. Liubakka A, Vaughn BP (July 2016). "Clostridium...
most of the enzymes involved in the pathway are known and involved in a metabolon complex. The pathway starts with a tryptophan precursor which is subsequently...
PMID 1722314. Sterling D, Reithmeier RA, Casey JR (Dec 2001). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate...
tetrachord effected a modulation of the system, hence the name systema metabolon, the modulating system, also called the Lesser Perfect System. This was...
Sterling, D; Reithmeier R A; Casey J R (December 2001). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate...
interconnected complexes have been identified. The first observation of a metabolon in fatty acid metabolism at high resolution came from cryo-electron microscopic...
BV, Casey JR (Jul 2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic...
software is the freely-available Java-based Mzmine application. Another is Metabolon, Inc’s commercial applications for metabolomic analysis using proprietary...
information on successful covalent protein coupling with help from SpyBank". Metabolons and Supramolecular Enzyme Assemblies. Methods in Enzymology. Vol. 617...
(July 2011). "Förster resonance energy transfer demonstrates a flavonoid metabolon in living plant cells that displays competitive interactions between enzymes"...
PMID 11248201. Sterling D, Reithmeier RA, Casey JR (2002). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate...
inactive enzymes in microfluidic channels. Another is the exploration of metabolon formation by studying the coordinated movement of the first four enzymes...
submitochondrial organization and therefore possibly affect mitochondrial metabolon organization. It has been found LACTB could cause obesity through gene...
(AE1 or Band 3) binds carbonic anhydrase II (CAII) forming a "transport metabolon" as CAII binding activates AE1 transport activity about 10 fold. AE1 is...
Nielsen AH, Bjarnholt N, Zagrobelny M, Bak S, Møller BL (June 2005). "Metabolon formation and metabolic channeling in the biosynthesis of plant natural...
Global Information